Seroatlas · Human Serome Atlas

ZNF786

Zinc finger protein 786

Also known as: DKFZp762I137, ZN786_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N393
Gene: ZNF786
Ensembl: ENSG00000197362
Chromosome: 7
Canonical length: 782 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Nuclear speckles,Nuclear bodies

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

782 residues, UniProt reviewed canonical sequence.

>Q8N393|ZNF786
     1  MAEPPRLPLT FEDVAIYFSE QEWQDLEAWQ KELYKHVMRS NYETLVSLDD GLPKPELISW
    61  IEHGGEPFRK WRESQKSGNI ICSSVDMHFD PGFEEQLFWG SQQAMNSGKT KSHFQLDPES
   121  QCSFGSFVSF RPDQGITLGS PQRHDARAPP PLACGPSEST LKEGIPGPRN LDLPGLWDVP
   181  AWESTQHPWP VCGESCWENN HLVMHQRGHS KDRTRRAWEK FNKRAETQMP WSSPRVQRHF
   241  RCGVCGKSFR RKLCLLRHLA AHTGRGPFRN ADGEMCFRHE LTHPSHRLPQ QGEKPAQCTP
   301  CGKRSLPVDS TQARRCQHSR EGPASWREGR GASSSVHSGQ KPGSRLPQEG NSHQEGDTEA
   361  LQHGAEGPCS CSECGERSPM SARLASPCRA HTGEKPFQCA HCTKRFRLRR LLQVHQHAHG
   421  GERPFSCRKC GKGFAKQCKL TEHIRVHSGE KPFRCAKCGR NFRQRGQLLR HQRLHTDEKP
   481  FQCPECGLSF RLESMLRAHR LRHGGERPFS CSECGRGFTH QCKLREHLRV HSGERPFQCL
   541  KCDKRFRLKG ILKAHQHTHS KERPFSCGEC GKGFTRQSKL TEHLRVHSGE RPFQCPECNR
   601  SFRLKGQLLS HQRLHTGERP FQCPECDKRY RVKADMKAHQ LLHSGEMPFS CECGKGFVKH
   661  SKLIEHIRTH TGEKPFQCPK CDKSFRLKAQ LLSHQGLHTG ERPFHCPECD KNFRERGHML
   721  RHQRIHRPER PFACGDCGKG FIYKSKLAEH IRVHTKSCPA PNELDIKKRL SQLFAMIEAD
   781  WS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF786 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 5.2 nTPM

Expression across tissuesHPA

Tissue

skin: 5.2 nTPM
cerebellum: 4.9 nTPM
cerebral cortex: 3.8 nTPM
lymph node: 3.6 nTPM
spleen: 3.4 nTPM
basal ganglia: 3.3 nTPM

Single-cell type

nk-cells: 34 nCPM
brain excitatory neurons: 30 nCPM
retinal amacrine cells: 28 nCPM
cone photoreceptor cells: 27 nCPM
rod photoreceptor cells: 27 nCPM
brain inhibitory neurons: 27 nCPM

Immune cell

gdT-cell: 10 nTPM
naive CD4 T-cell: 9.7 nTPM
memory CD8 T-cell: 9.4 nTPM
MAIT T-cell: 8.8 nTPM
NK-cell: 8.5 nTPM
naive CD8 T-cell: 8.3 nTPM

Brain region

cerebral cortex: 15 nTPM
cerebellum: 14 nTPM
basal ganglia: 11 nTPM
hypothalamus: 11 nTPM
hippocampal formation: 11 nTPM
white matter: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -1.45
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF786 as an antibody target. Whether an autoantibody or antibody against ZNF786 could matter depends on whether native ZNF786 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF786 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF786 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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