Seroatlas · Human Serome Atlas

ZFP64

Zinc finger protein 64

Also known as: dJ548G19.1, dJ831D17.1, FLJ10734, FLJ12628, ZF64B_HUMAN, ZNF338

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NTW7
Gene: ZFP64
Ensembl: ENSG00000020256
Chromosome: 20
Canonical length: 645 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Involved in mesenchymal cell differentiation. Located in cytoplasm and megasporocyte nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

645 residues, UniProt reviewed canonical sequence.

>Q9NTW7|ZFP64
     1  MNASSEGESF AGSVQIPGGT TVLVELTPDI HICGICKQQF NNLDAFVAHK QSGCQLTGTS
    61  AAAPSTVQFV SEETVPATQT QTTTRTITSE TQTITVSAPE FVFEHGYQTY LPTESNENQT
   121  ATVISLPAKS RTKKPTTPPA QKRLNCCYPG CQFKTAYGMK DMERHLKIHT GDKPHKCEVC
   181  GKCFSRKDKL KTHMRCHTGV KPYKCKTCDY AAADSSSLNK HLRIHSDERP FKCQICPYAS
   241  RNSSQLTVHL RSHTASELDD DVPKANCLST ESTDTPKAPV ITLPSEAREQ MATLGERTFN
   301  CCYPGCHFKT VHGMKDLDRH LRIHTGDKPH KCEFCDKCFS RKDNLTMHMR CHTSVKPHKC
   361  HLCDYAAVDS SSLKKHLRIH SDERPYKCQL CPYASRNSSQ LTVHLRSHTG DTPFQCWLCS
   421  AKFKISSDLK RHMIVHSGEK PFKCEFCDVR CTMKANLKSH IRIKHTFKCL HCAFQGRDRA
   481  DLLEHSRLHQ ADHPEKCPEC SYSCSSAAAL RVHSRVHCKD RPFKCDFCSF DTKRPSSLAK
   541  HVDKVHRDEA KTENRAPLGK EGLREGSSQH VAKIVTQRAF RCETCGASFV RDDSLRCHKK
   601  QHSDQSENKN SDLVTFPPES GASGQLSTLV SVGQLEAPLE PSQDL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP64 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

skin: 10 nTPM
ovary: 7 nTPM
thymus: 6.8 nTPM
esophagus: 6.7 nTPM
parathyroid gland: 6.7 nTPM
fallopian tube: 6.3 nTPM

Single-cell type

oocytes: 124 nCPM
renal collecting duct intercalated cells: 64 nCPM
thyrotrophs: 59 nCPM
adipocytes: 58 nCPM
medullary thymic epithelial cells: 58 nCPM
adrenal cortex cells: 53 nCPM

Immune cell

eosinophil: 8 nTPM
NK-cell: 5.2 nTPM
memory B-cell: 5 nTPM
non-classical monocyte: 4.7 nTPM
basophil: 4.6 nTPM
gdT-cell: 4.4 nTPM

Brain region

basal ganglia: 29 nTPM
cerebral cortex: 28 nTPM
cerebellum: 27 nTPM
white matter: 27 nTPM
pons: 27 nTPM
thalamus: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0
gnomAD missense Z: 1.94
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFP64 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP64 as an antibody target. Whether an autoantibody or antibody against ZFP64 could matter depends on whether native ZFP64 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP64 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP64 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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