Seroatlas · Human Serome Atlas

ZNF257

Zinc finger protein 257

Also known as: BMZF-4, ZN257_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y2Q1
Gene: ZNF257
Ensembl: ENSG00000197134
Chromosome: 19
Canonical length: 563 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

563 residues, UniProt reviewed canonical sequence.

>Q9Y2Q1|ZNF257
     1  MGPLTIRDVT VEFSLEEWHC LDTAQQNLYR DVMLENYRNL VFLGIAVSKP DLITCLEQGK
    61  EPCNMKRHEM VAKPPVMCSH IAEDLCPERD IKYFFQKVIL RRYDKCEHEN LQLRKGCKSV
   121  DECKVCKGGY NGLNQCLITT QSKMYQCDKY VKVFYKFSNS DRHKIRHTEK KTCKCKECGK
   181  SFCMLSQLTR HKRIHIRENS HKCEECGKAF NQSSALTRHK MTHTGEKPYK CEECGKAFNR
   241  SSHLTQHKVI HTREKPYKCE ECGKAFNRSS HITQHKRIHN REKPFKYDEC CKAFKWSSAL
   301  TTLTQHKRIH TGEKPYKCEE CGKAFNQSSA LTRHKMIHTG EKPFQCEECG KAFNRSSHLT
   361  QHKIIHTKEK PYKCEECGKA FNRSSHLTKH KRIHTREKAY KCDEYCKAFN WSSALTTLTQ
   421  HKIIHTGEKP YKCEECGKAF NRSSYLIRHK IIHTGEKPYK CEECGKAFNQ SSHLTQHKII
   481  HTGEKPYKCE ECGKAFNRSS HLSQHKIIHT GEKPYKCEEC GKPFNRFSYL TVHKRIHAGE
   541  NPNKYEECGK ACNHSSNLTK HNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF257 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 3.9 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 3.9 nTPM
testis: 2.5 nTPM
lymph node: 2.4 nTPM
ovary: 2.3 nTPM
thyroid gland: 2.1 nTPM
pancreas: 2 nTPM

Single-cell type

platelets: 120 nCPM
megakaryocytes: 56 nCPM
neutrophils: 41 nCPM
early primary spermatocytes: 35 nCPM
hematopoietic stem cells: 23 nCPM
neutrophil progenitors: 21 nCPM

Immune cell

basophil: 2.7 nTPM
memory B-cell: 2.5 nTPM
naive B-cell: 2 nTPM
neutrophil: 1.8 nTPM
eosinophil: 1.4 nTPM
naive CD4 T-cell: 1.4 nTPM

Brain region

cerebellum: 4 nTPM
white matter: 4 nTPM
pons: 3.8 nTPM
medulla oblongata: 3.6 nTPM
midbrain: 3.6 nTPM
basal ganglia: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.51
gnomAD pLI: 0.02
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of DNA-templated transcription

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF257 as an antibody target. Whether an autoantibody or antibody against ZNF257 could matter depends on whether native ZNF257 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF257 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF257 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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