Seroatlas · Human Serome Atlas

ZFP62

Zinc finger protein 62 homolog

Also known as: FLJ34231, ZET, ZFP62_HUMAN, ZNF755

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NB50
Gene: ZFP62
Ensembl: ENSG00000196670
Chromosome: 5
Canonical length: 900 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Actin filaments

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

900 residues, UniProt reviewed canonical sequence.

>Q8NB50|ZFP62
     1  MSHLKTSTED EEPTEEYENV GNAASKWPKV EDPMPESKVG DTCVWDSKVE NQQKKPVENR
    61  MKEDKSSIRE AISKAKSTAN IKTEQEGEAS EKSLHLSPQH ITHQTMPIGQ RGSEQGKRVE
   121  NINGTSYPSL QQKTNAVKKL HKCDECGKSF KYNSRLVQHK IMHTGEKRYE CDDCGGTFRS
   181  SSSLRVHKRI HTGEKPYKCE ECGKAYMSYS SLINHKSTHS GEKNCKCDEC GKSFNYSSVL
   241  DQHKRIHTGE KPYECGECGK AFRNSSGLRV HKRIHTGEKP YECDICGKTF SNSSGLRVHK
   301  RIHTGEKPYE CDECGKAFIT CRTLLNHKSI HFGDKPYKCD ECEKSFNYSS LLIQHKVIHT
   361  GEKPYECDEC GKAFRNSSGL IVHKRIHTGE KPYKCDVCGK AFSYSSGLAV HKSIHPGKKA
   421  HECKECGKSF SYNSLLLQHR TIHTGERPYV CDVCGKTFRN NAGLKVHRRL HTGEKPYKCD
   481  VCGKAYISRS SLKNHKGIHL GEKPYKCSYC EKSFNYSSAL EQHKRIHTRE KPFGCDECGK
   541  AFRNNSGLKV HKRIHTGERP YKCEECGKAY ISLSSLINHK SVHPGEKPFK CDECEKAFIT
   601  YRTLTNHKKV HLGEKPYKCD VCEKSFNYTS LLSQHRRVHT REKPYECDRC EKVFRNNSSL
   661  KVHKRIHTGE RPYECDVCGK AYISHSSLIN HKSTHPGRTP HTCDECGKAF FSSRTLISHK
   721  RVHLGEKPFK CVECGKSFSY SSLLSQHKRI HTGEKPYVCD RCGKAFRNSS GLTVHKRIHT
   781  GEKPYECDEC GKAYISHSSL INHKSVHQGK QPYNCECGKS FNYRSVLDQH KRIHTGKKPY
   841  RCNECGKAFN IRSNLTKHKR THTGEESLNV IYVGSYSGTS QKRTYEGGNA LDGGRMRMPL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP62 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

thymus: 23 nTPM
thyroid gland: 22 nTPM
tonsil: 19 nTPM
lymph node: 17 nTPM
retina: 17 nTPM
ovary: 17 nTPM

Single-cell type

oocytes: 69 nCPM
epididymal principal cells: 57 nCPM
late primary spermatocytes: 42 nCPM
late spermatids: 37 nCPM
esophageal apical cells: 25 nCPM
gastric chief cells: 25 nCPM

Immune cell

basophil: 6.9 nTPM
naive CD4 T-cell: 6.1 nTPM
naive CD8 T-cell: 5.5 nTPM
MAIT T-cell: 4.8 nTPM
naive B-cell: 4.8 nTPM
memory B-cell: 4.4 nTPM

Brain region

cerebellum: 36 nTPM
cerebral cortex: 34 nTPM
white matter: 31 nTPM
hypothalamus: 31 nTPM
basal ganglia: 28 nTPM
medulla oblongata: 28 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.58
gnomAD missense Z: 2.15
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP62 as an antibody target. Whether an autoantibody or antibody against ZFP62 could matter depends on whether native ZFP62 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP62 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP62 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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