Seroatlas · Human Serome Atlas

ZNF615

Zinc finger protein 615

Also known as: FLJ33710, ZN615_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N8J6
Gene: ZNF615
Ensembl: ENSG00000197619
Chromosome: 19
Canonical length: 731 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

731 residues, UniProt reviewed canonical sequence.

>Q8N8J6|ZNF615
     1  MMQAQESLTL EDVAVDFTWE EWQFLSPAQK DLYRDVMLEN YSNLVAVGYQ ASKPDALSKL
    61  ERGEETCTTE DEIYSRICSE IRKIDDPLQH HLQNQSIQKS VKQCHEQNMF GNIVNQNKGH
   121  FLLKQDCDTF DLHEKPLKSN LSFENQKRSS GLKNSAEFNR DGKSLFHANH KQFYTEMKFP
   181  AIAKPINKSQ FIKQQRTHNI ENAHVCSECG KAFLKLSQFI DHQRVHTGEK PHVCSMCGKA
   241  FSRKSRLMDH QRTHTELKHY ECTECDKTFL KKSQLNIHQK THMGGKPYTC SQCGKAFIKK
   301  CRLIYHQRTH TGEKPHGCSV CGKAFSTKFS LTTHQKTHTG EKPYICSECG KGFIEKRRLT
   361  AHHRTHTGEK PFICNKCGKG FTLKNSLITH QQTHTGEKLY TCSECGKGFS MKHCLMVHQR
   421  THTGEKPYKC NECGKGFALK SPLIRHQRTH TGEKPYVCTE CRKGFTMKSD LIVHQRTHTA
   481  EKPYICNDCG KGFTVKSRLI VHQRTHTGEK PYVCGECGKG FPAKIRLMGH QRTHTGEKPY
   541  ICNECGKGFT EKSHLNVHRR THTGEKPYVC SECGKGLTGK SMLIAHQRTH TGEKPYICNE
   601  CGKGFTMKST LSIHQQTHTG EKPYKCNECD KTFRKKTCLI QHQRFHTGKT SFACTECGKF
   661  SLRKNDLITH QRIHTGEKPY KCSDCGKAFT TKSGLNVHQR KHTGERPYGC SDCGKAFAHL
   721  SILVKHRRIH R

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF615 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

prostate: 16 nTPM
parathyroid gland: 9.5 nTPM
retina: 9.1 nTPM
ovary: 7.8 nTPM
endometrium: 7.4 nTPM
thyroid gland: 7.1 nTPM

Single-cell type

prostatic glandular cells: 29 nCPM
cardiomyocytes: 17 nCPM
lactotrophs: 15 nCPM
renal connecting tubule cells: 15 nCPM
oligodendrocytes: 15 nCPM
thyrotrophs: 15 nCPM

Immune cell

NK-cell: 8.2 nTPM
basophil: 5.8 nTPM
MAIT T-cell: 5.3 nTPM
memory CD4 T-cell: 4.5 nTPM
naive CD4 T-cell: 4.4 nTPM
eosinophil: 4.2 nTPM

Brain region

cerebellum: 32 nTPM
white matter: 30 nTPM
basal ganglia: 27 nTPM
hypothalamus: 26 nTPM
cerebral cortex: 25 nTPM
thalamus: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF615 as an antibody target. Whether an autoantibody or antibody against ZNF615 could matter depends on whether native ZNF615 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF615 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF615 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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