Seroatlas · Human Serome Atlas

ZNF214

Zinc finger protein 214

Also known as: ZN214_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UL59
Gene: ZNF214
Ensembl: ENSG00000149050
Chromosome: 11
Canonical length: 606 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Midbody

OverviewNCBI Gene

This gene is expressed predominantly in the testis and encodes a zinc finger protein that contains an N-terminal kruppel-associated box A (KRABA) domain and twelve zinc finger domains. This gene is located within one of three regions on chromosome 11p15 associated with Beckwith-Wiedemann syndrome, called Beckwith-Wiedemann syndrome chromosome region-2 (BWSCR2), and is thought to play a role in the etiology of this disease. [provided by RefSeq, Aug 2017]

Canonical amino-acid sequenceUniProt

606 residues, UniProt reviewed canonical sequence.

>Q9UL59|ZNF214
     1  MAVTFEDVTI IFTWEEWKFL DSSQKRLYRE VMWENYTNVM SVENWNESYK SQEEKFRYLE
    61  YENFSYWQGW WNAGAQMYEN QNYGETVQGT DSKDLTQQDR SQCQEWLILS TQVPGYGNYE
   121  LTFESKSLRN LKYKNFMPWQ SLETKTTQDY GREIYMSGSH GFQGGRYRLG ISRKNLSMEK
   181  EQKLIVQHSY IPVEEALPQY VGVICQEDLL RDSMEEKYCG CNKCKGIYYW NSRCVFHKRN
   241  QPGENLCQCS ICKACFSQRS DLYRHPRNHI GKKLYGCDEV DGNFHQSSGV HFHQRVHIGE
   301  VPYSCNACGK SFSQISSLHN HQRVHTEEKF YKIECDKDLS RNSLLHIHQR LHIGEKPFKC
   361  NQCGKSFNRS SVLHVHQRVH TGEKPYKCDE CGKGFSQSSN LRIHQLVHTG EKSYKCEDCG
   421  KGFTQRSNLQ IHQRVHTGEK PYKCDDCGKD FSHSSDLRIH QRVHTGEKPY TCPECGKGFS
   481  KSSKLHTHQR VHTGEKPYKC EECGKGFSQR SHLLIHQRVH TGEKPYKCHD CGKGFSHSSN
   541  LHIHQRVHTG EKPYQCAKCG KGFSHSSALR IHQRVHAGEK PYKCREYYKG FDHNSHLHNN
   601  HRRGNL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF214 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 4.9 nTPM

Expression across tissuesHPA

Tissue

retina: 4.9 nTPM
fallopian tube: 3.6 nTPM
ovary: 3.5 nTPM
thyroid gland: 3.2 nTPM
testis: 2.9 nTPM
epididymis: 2.5 nTPM

Single-cell type

respiratory ciliated cells: 54 nCPM
ependymal cells: 47 nCPM
fallopian tube ciliated cells: 34 nCPM
late primary spermatocytes: 28 nCPM
epididymal efferent duct ciliated cells: 22 nCPM
rod photoreceptor cells: 20 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 4.6 nTPM
choroid plexus: 4.5 nTPM
midbrain: 4.2 nTPM
white matter: 3.5 nTPM
spinal cord: 3.2 nTPM
basal ganglia: 3.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: -0.59
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF214 as an antibody target. Whether an autoantibody or antibody against ZNF214 could matter depends on whether native ZNF214 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF214 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF214 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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