Seroatlas · Human Serome Atlas

ZNF181

Zinc finger protein 181

Also known as: HHZ181, MGC44316, ZN181_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q2M3W8
Gene: ZNF181
Ensembl: ENSG00000197841
Chromosome: 19
Canonical length: 571 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Zinc finger proteins have been shown to interact with nucleic acids and to have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See MIM 604749 for additional information on zinc finger proteins.[supplied by OMIM, Jul 2003]

Canonical amino-acid sequenceUniProt

571 residues, UniProt reviewed canonical sequence.

>Q2M3W8|ZNF181
     1  MPQVTFNDVA IDFTHEEWGW LSSAQRDLYK DVMVQNYENL VSVAGLSVTK PYVITLLEDG
    61  KEPWMMEKKL SKGMIPDWES RWENKELSTK KDNYDEDSPQ TVIIEKVVKQ SYEFSNSKKN
   121  LEYIEKLEGK HGSQVDHFRP AILTSRESPT ADSVYKYNIF RSTFHSKSTL SEPQKISAEG
   181  NSHKYDILKK NLPKKSVIKN EKVNGGKKLL NSNKSGAAFS QGKSLTLPQT CNREKIYTCS
   241  ECGKAFGKQS ILNRHWRIHT GEKPYECREC GKTFSHGSSL TRHLISHSGE KPYKCIECGK
   301  AFSHVSSLTN HQSTHTGEKP YECMNCGKSF SRVSHLIEHL RIHTQEKLYE CRICGKAFIH
   361  RSSLIHHQKI HTGEKPYECR ECGKAFCCSS HLTRHQRIHT MEKQYECNKC LKVFSSLSFL
   421  VQHQSIHTEE KPFECQKCRK SFNQLESLNM HLRNHIRLKP YECSICGKAF SHRSSLLQHH
   481  RIHTGEKPYE CIKCGKTFSC SSNLTVHQRI HTGEKPYKCN ECGKAFSKGS NLTAHQRVHN
   541  GEKPNSVVSV EKPLDYMNHY TCEKSYRRET V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF181 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

tongue: 22 nTPM
skeletal muscle: 21 nTPM
retina: 16 nTPM
ovary: 15 nTPM
liver: 14 nTPM
heart muscle: 13 nTPM

Single-cell type

cardiomyocytes: 31 nCPM
oocytes: 28 nCPM
smooth muscle cells: 23 nCPM
myonuclei: 22 nCPM
medullary thymic epithelial cells: 22 nCPM
thymic myoid cells: 19 nCPM

Immune cell

naive CD4 T-cell: 17 nTPM
non-classical monocyte: 16 nTPM
naive B-cell: 15 nTPM
naive CD8 T-cell: 12 nTPM
memory CD8 T-cell: 11 nTPM
memory CD4 T-cell: 11 nTPM

Brain region

cerebellum: 22 nTPM
white matter: 22 nTPM
basal ganglia: 19 nTPM
medulla oblongata: 18 nTPM
midbrain: 17 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.41
gnomAD pLI: 0
gnomAD missense Z: 0.39
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF181 as an antibody target. Whether an autoantibody or antibody against ZNF181 could matter depends on whether native ZNF181 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF181 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF181 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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