Seroatlas · Human Serome Atlas

ZNF865

Zinc finger protein 865

Also known as: ZN865_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P0CJ78
Gene: ZNF865
Ensembl: ENSG00000261221
Chromosome: 19
Canonical length: 1059 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli

OverviewNCBI Gene

Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1059 residues, UniProt reviewed canonical sequence.

>P0CJ78|ZNF865
     1  MEANPAGSGA GGGGSSGIGG EDGVHFQSYP FDFLEFLNHQ RFEPMELYGE HAKAVAALPC
    61  APGPPPQPPP QPPPPQYDYP PQSTFKPKAE VPSSSSSSSS SSSSSSSSSS SSSSSSSQAK
   121  KPDPPLPPAF GAPPPPLFDA AFPTPQWGIV DLSGHQHLFG NLKRGGPASG PGVTPGLGAP
   181  AGAPGPLPAP SQTPPGPPAA AACDPTKDDK GYFRRLKYLM ERRFPCGVCQ KSFKQSSHLV
   241  QHMLVHSGER PYECGVCGRT YNHVSSLIRH RRCHKDVPPA AGGPPQPGPH LPPLGLPAPA
   301  ASAATAAAPS TVSSGPPATP VAPAPSADGS AAPAGVGVPP PATGGGDGPF ACPLCWKVFK
   361  KPSHLHQHQI IHTGEKPFSC SVCSKSFNRR ESLKRHVKTH SADLLRLPCG ICGKAFRDAS
   421  YLLKHQAAHA GAGAGGPRPV YPCDLCGKSY SAPQSLLRHK AAHAPPAAAA EAPKDGAASA
   481  PQPPPTFPPG PYLLPPDPPT TDSEKAAAAA AAVVYGAVPV PLLGAHPLLL GGAGTSGAGG
   541  SGASVPGKTF CCGICGRGFG RRETLKRHER IHTGEKPHQC PVCGKRFRES FHLSKHHVVH
   601  TRERPYKCEL CGKVFGYPQS LTRHRQVHRL QLPCALAGAA GLPSTQGTPG ACGPGASGTS
   661  AGPTDGLSYA CSDCGEHFPD LFHVMSHKEV HMAEKPYGCD ACGKTFGFIE NLMWHKLVHQ
   721  AAPERLLPPA PGGLQPPDGS SGTDAASVLD NGLAGEVGAA VAALAGVSGG EDAGGAAVAG
   781  AGGGASSGPE RFSCATCGQS FKHFLGLVTH KYVHLVRRTL GCGLCGQSFA GAYDLLLHRR
   841  SHRQKRGFRC PVCGKRFWEA ALLMRHQRCH TEQRPYRCGV CGRGFLRSWY LRQHRVVHTG
   901  ERAFKCGVCA KRFAQSSSLA EHRRLHAVAR PQRCSACGKT FRYRSNLLEH QRLHLGERAY
   961  RCEHCGKGFF YLSSVLRHQR AHEPPRPELR CPACLKAFKD PGYFRKHLAA HQGGRPFRCS
  1021  SCGEGFANTY GLKKHRLAHK AENLGGPGAG AGTLAGKDA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF865 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 36 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 36 nTPM
heart muscle: 16 nTPM
cerebellum: 14 nTPM
spleen: 13 nTPM
colon: 13 nTPM
endometrium: 13 nTPM

Single-cell type

late spermatids: 156 nCPM
thymic myoid cells: 26 nCPM
late primary spermatocytes: 25 nCPM
early spermatids: 22 nCPM
neutrophil progenitors: 19 nCPM
neutrophils: 18 nCPM

Immune cell

eosinophil: 0.2 nTPM
memory B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 27 nTPM
cerebellum: 26 nTPM
medulla oblongata: 26 nTPM
amygdala: 26 nTPM
thalamus: 25 nTPM
white matter: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZNF865.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 151 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

ZNF865-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.16
gnomAD pLI: 1
gnomAD missense Z: 3.91
DepMap mean gene effect: -0.05
DepMap dependency class: selective

OntologyGO

Biological processes

regulation of transcription by RNA polymerase II

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF865 as an antibody target. Whether an autoantibody or antibody against ZNF865 could matter depends on whether native ZNF865 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF865 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF865 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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