Seroatlas · Human Serome Atlas

ZNF574

Zinc finger protein 574

Also known as: FLJ22059, ZN574_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZN55
Gene: ZNF574
Ensembl: ENSG00000105732
Chromosome: 19
Canonical length: 896 aa
Protein class: Predicted intracellular proteins, Transcription factors
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

896 residues, UniProt reviewed canonical sequence.

>Q6ZN55|ZNF574
     1  MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLMHQNSHVP QQHFELVGVA DPGVTVATDT
    61  ASGTGLYQTL VQESQYQCLE CGQLLMSPSQ LLEHQELHLK MMAPQEAVPA EPSPKAPPLS
   121  SSTIHYECVD CKALFASQEL WLNHRQTHLR ATPTKAPAPV VLGSPVVLGP PVGQARVAVE
   181  HSYRKAEEGG EGATVPSAAA TTTEVVTEVE LLLYKCSECS QLFQLPADFL EHQATHFPAP
   241  VPESQEPALQ QEVQASSPAE VPVSQPDPLP ASDHSYELRN GEAIGRDRRG RRARRNNSGE
   301  AGGAATQELF CSACDQLFLS PHQLQQHLRS HREGVFKCPL CSRVFPSPSS LDQHLGDHSS
   361  ESHFLCVDCG LAFGTEALLL AHRRAHTPNP LHSCPCGKTF VNLTKFLYHR RTHGVGGVPL
   421  PTTPVPPEEP VIGFPEPAPA ETGEPEAPEP PVSEETSAGP AAPGTYRCLL CSREFGKALQ
   481  LTRHQRFVHR LERRHKCSIC GKMFKKKSHV RNHLRTHTGE RPFPCPDCSK PFNSPANLAR
   541  HRLTHTGERP YRCGDCGKAF TQSSTLRQHR LVHAQHFPYR CQECGVRFHR PYRLLMHRYH
   601  HTGEYPYKCR ECPRSFLLRR LLEVHQLVVH AGRQPHRCPS CGAAFPSSLR LREHRCAAAA
   661  AQAPRRFECG TCGKKVGSAA RLQAHEAAHA AAGPGEVLAK EPPAPRAPRA TRAPVASPAA
   721  LGSTATASPA APARRRGLEC SECKKLFSTE TSLQVHRRIH TGERPYPCPD CGKAFRQSTH
   781  LKDHRRLHTG ERPFACEVCG KAFAISMRLA EHRRIHTGER PYSCPDCGKS YRSFSNLWKH
   841  RKTHQQQHQA AVRQQLAEAE AAVGLAVMET AVEALPLVEA IEIYPLAEAE GVQISG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZNF574 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

testis: 27 nTPM
skin: 13 nTPM
cerebellum: 12 nTPM
endometrium: 10 nTPM
bone marrow: 10 nTPM
esophagus: 9.4 nTPM

Single-cell type

early primary spermatocytes: 133 nCPM
late primary spermatocytes: 50 nCPM
undifferentiated spermatogonia: 31 nCPM
differentiating spermatogonia: 30 nCPM
paneth cells: 23 nCPM
late spermatids: 23 nCPM

Immune cell

memory CD8 T-cell: 18 nTPM
MAIT T-cell: 18 nTPM
memory B-cell: 17 nTPM
eosinophil: 17 nTPM
gdT-cell: 16 nTPM
neutrophil: 13 nTPM

Brain region

cerebellum: 22 nTPM
cerebral cortex: 17 nTPM
medulla oblongata: 17 nTPM
basal ganglia: 17 nTPM
midbrain: 16 nTPM
hypothalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.51
gnomAD pLI: 0.08
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.6
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

nucleus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZNF574 as an antibody target. Whether an autoantibody or antibody against ZNF574 could matter depends on whether native ZNF574 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZNF574 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZNF574 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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