Immune Recognition and Response Modulators
IPR050380
Definition
This family of proteins includes components involved in the immune system's recognition and response to antigens. Members function as receptors on B and T lymphocytes, recognizing specific antigens to initiate adaptive immune responses. They also serve as effector molecules, mediating various immune functions such as antigen presentation, hypersensitivity reactions, and antibody-dependent cellular cytotoxicity. Some members are involved in the assembly and stabilization of major histocompatibility complex (MHC) class I molecules, facilitating antigen processing and presentation. Others are implicated in mucosal immunity, complement activation, and the clearance of pathogens and apoptotic cells. The family encompasses a range of immunoglobulins with distinct roles in humoral immunity, as well as proteins that interact with natural killer cells to trigger immune activation.
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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