IGHA2
Immunoglobulin heavy constant alpha 2
Also known as: IGHA2_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P01877
- Gene
- IGHA2
- Ensembl
- ENSG00000211890
- Chromosome
- 14
- Canonical length
- 391 aa
- Protein class
- Immunoglobulin genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
- Secretome location
- Immunoglobulin genes
OverviewNCBI Gene
Contributes to immunoglobulin receptor binding activity. Involved in glomerular filtration and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
391 residues, UniProt reviewed canonical sequence.
>P01877|IGHA2
1 ASPTSPKVFP LSLDSTPQDG NVVVACLVQG FFPQEPLSVT WSESGQNVTA RNFPPSQDAS
61 GDLYTTSSQL TLPATQCPDG KSVTCHVKHY TNSSQDVTVP CRVPPPPPCC HPRLSLHRPA
121 LEDLLLGSEA NLTCTLTGLR DASGATFTWT PSSGKSAVQG PPERDLCGCY SVSSVLPGCA
181 QPWNHGETFT CTAAHPELKT PLTANITKSG NTFRPEVHLL PPPSEELALN ELVTLTCLAR
241 GFSPKDVLVR WLQGSQELPR EKYLTWASRQ EPSQGTTTYA VTSILRVAAE DWKKGETFSC
301 MVGHEALPLA FTQKTIDRMA GSCCVADWQM PPPYVVLDLP QETLEEETPG ANLWPTTITF
361 LTLFLLSLFY STALTVTSVR GPSGKREGPQ YLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 5,010 nTPM
Expression across tissuesHPA
Tissue
- colon: 5,010 nTPM
- salivary gland: 3,591 nTPM
- small intestine: 2,124 nTPM
- stomach: 671 nTPM
- spleen: 644 nTPM
- breast: 247 nTPM
Single-cell type
- plasma cells: 8,043 nCPM
- parietal cells: 1,496 nCPM
- gastric chief cells: 801 nCPM
- foveolar cells: 670 nCPM
- mucous neck cells: 187 nCPM
- b-cells: 75 nCPM
Immune cell
- memory B-cell: 280 nTPM
- naive B-cell: 125 nTPM
- total PBMC: 13 nTPM
- MAIT T-cell: 0.2 nTPM
- neutrophil: 0.2 nTPM
- basophil: 0.1 nTPM
Brain region
- basal ganglia: 0.1 nTPM
- cerebral cortex: 0.1 nTPM
- hippocampal formation: 0.1 nTPM
- pons: 0.1 nTPM
- amygdala: 0 nTPM
- cerebellum: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about IGHA2.
Disease | ImmuneIEDB
Conditions an epitope on IGHA2 was assayed in.
- rheumatoid arthritis B cell
OntologyGO
Biological processes
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
- complement activation, classical pathway
- glomerular filtration
- immune response
- positive regulation of respiratory burst
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin C1-set
- Immunoglobulin-like domain
- Immunoglobulin-like beta-sandwich domain
- Immunoglobulin-like fold
- Immunoglobulin-like domain superfamily
- Immune Recognition and Response Modulators
- Immunoglobulin domain
- Immunoglobulin C1-set domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHA2 as an antibody target. Whether an autoantibody or antibody against IGHA2 could matter depends on whether native IGHA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHA2 is annotated at the cell surface, where native IGHA2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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