Seroatlas · Human Serome Atlas

TRBC1

T cell receptor beta constant 1

Also known as: BV05S1J2.2, TCRBC1, TRBC1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01850
Gene
TRBC1
Ensembl
ENSG00000211751
Chromosome
7
Canonical length
176 aa
Protein class
Predicted membrane proteins, T-cell receptor genes
Quaternary structure
Homodimer

OverviewNCBI Gene

Predicted to be involved in T cell receptor signaling pathway; adaptive immune response; and alpha-beta T cell activation. Predicted to be located in plasma membrane. Predicted to be part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

176 residues, UniProt reviewed canonical sequence.

>P01850|TRBC1
     1  DLNKVFPPEV AVFEPSEAEI SHTQKATLVC LATGFFPDHV ELSWWVNGKE VHSGVSTDPQ
    61  PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY GLSENDEWTQ DRAKPVTQIV
   121  SAEAWGRADC GFTSVSYQQG VLSATILYEI LLGKATLYAV LVSALVLMAM VKRKDF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
1,415 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 1,415 nTPM
  • lymph node: 302 nTPM
  • tonsil: 213 nTPM
  • appendix: 132 nTPM
  • spleen: 87 nTPM
  • bone marrow: 50 nTPM

Single-cell type

  • t-cells: 232 nCPM
  • innate lymphoid cells: 165 nCPM
  • nk-cells: 148 nCPM
  • pdcs: 15 nCPM
  • thymocytes: 13 nCPM
  • leydig cells: 11 nCPM

Immune cell

  • T-reg: 3,242 nTPM
  • naive CD4 T-cell: 1,996 nTPM
  • total PBMC: 1,919 nTPM
  • memory CD4 T-cell: 1,899 nTPM
  • naive CD8 T-cell: 1,456 nTPM
  • memory CD8 T-cell: 1,259 nTPM

Brain region

  • white matter: 2.4 nTPM
  • medulla oblongata: 2.3 nTPM
  • spinal cord: 2 nTPM
  • pons: 1.8 nTPM
  • thalamus: 1.7 nTPM
  • basal ganglia: 1.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TRBC1.

Disease | ImmuneIEDB

Conditions an epitope on TRBC1 was assayed in.

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBC1 as an antibody target. Whether an autoantibody or antibody against TRBC1 could matter depends on whether native TRBC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBC1 is annotated at the cell surface, where native TRBC1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TRBC1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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