Seroatlas · Human Serome Atlas

IGHA1

Immunoglobulin heavy constant alpha 1

Also known as: AL928768.3, IGHA1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01876
Gene: IGHA1
Ensembl: ENSG00000211895
Chromosome: 14
Canonical length: 398 aa
Protein class: Disease related genes, Immunoglobulin genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Contributes to immunoglobulin receptor binding activity. Involved in glomerular filtration and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

398 residues, UniProt reviewed canonical sequence.

>P01876|IGHA1
     1  ASPTSPKVFP LSLCSTQPDG NVVIACLVQG FFPQEPLSVT WSESGQGVTA RNFPPSQDAS
    61  GDLYTTSSQL TLPATQCLAG KSVTCHVKHY TNPSQDVTVP CPVPSTPPTP SPSTPPTPSP
   121  SCCHPRLSLH RPALEDLLLG SEANLTCTLT GLRDASGVTF TWTPSSGKSA VQGPPERDLC
   181  GCYSVSSVLP GCAEPWNHGK TFTCTAAYPE SKTPLTATLS KSGNTFRPEV HLLPPPSEEL
   241  ALNELVTLTC LARGFSPKDV LVRWLQGSQE LPREKYLTWA SRQEPSQGTT TFAVTSILRV
   301  AAEDWKKGDT FSCMVGHEAL PLAFTQKTID RLADWQMPPP YVVLDLPQET LEEETPGANL
   361  WPTTITFLTL FLLSLFYSTA LTVTSVRGPS GNREGPQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 8,576 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 8,576 nTPM
duodenum: 6,976 nTPM
stomach: 6,273 nTPM
colon: 5,965 nTPM
spleen: 5,886 nTPM
small intestine: 3,605 nTPM

Single-cell type

plasma cells: 9,026 nCPM
parietal cells: 476 nCPM
gastric chief cells: 325 nCPM
b-cells: 105 nCPM
foveolar cells: 66 nCPM
mast cells: 65 nCPM

Immune cell

memory B-cell: 2,579 nTPM
naive B-cell: 1,123 nTPM
total PBMC: 508 nTPM
neutrophil: 9.1 nTPM
basophil: 3.8 nTPM
classical monocyte: 3 nTPM

Brain region

cerebral cortex: 10 nTPM
choroid plexus: 6.5 nTPM
medulla oblongata: 4.9 nTPM
white matter: 2.3 nTPM
spinal cord: 1.8 nTPM
amygdala: 1.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGHA1.

Disease | ImmuneIEDB

Conditions an epitope on IGHA1 was assayed in.

OntologyGO

Biological processes

Molecular functions

antigen binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHA1 as an antibody target. Whether an autoantibody or antibody against IGHA1 could matter depends on whether native IGHA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHA1 is annotated at the cell surface, where native IGHA1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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