Seroatlas · Human Serome Atlas

IGKC

Immunoglobulin kappa constant

Also known as: IGKC_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P01834
Gene
IGKC
Canonical length
107 aa
Protein class
Immunoglobulin genes, Predicted intracellular proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for IGKC in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>P01834|IGKC
     1  RTVAAPSVFI FPPSDEQLKS GTASVVCLLN NFYPREAKVQ WKVDNALQSG NSQESVTEQD
    61  SKDSTYSLSS TLTLSKADYE KHKVYACEVT HQGLSSPVTK SFNRGEC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGKC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Highest tissue expression
58,910 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 58,910 nTPM
  • colon: 32,939 nTPM
  • rectum: 28,679 nTPM
  • spleen: 25,399 nTPM
  • urinary bladder: 23,289 nTPM
  • duodenum: 23,017 nTPM

Single-cell type

  • plasma cells: 2,434 nCPM
  • gastric chief cells: 109 nCPM
  • parietal cells: 37 nCPM
  • b-cells: 25 nCPM
  • neuroendocrine cells: 22 nCPM
  • mucous neck cells: 17 nCPM

Immune cell

  • memory B-cell: 39,310 nTPM
  • naive B-cell: 35,339 nTPM
  • total PBMC: 8,581 nTPM
  • plasmacytoid DC: 1,741 nTPM
  • neutrophil: 66 nTPM
  • classical monocyte: 56 nTPM

Brain region

  • spinal cord: 57 nTPM
  • cerebral cortex: 42 nTPM
  • choroid plexus: 33 nTPM
  • medulla oblongata: 28 nTPM
  • white matter: 18 nTPM
  • midbrain: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGKC.

Disease | AllUniProt

Conditions IGKC is implicated in, by any mechanism.

  • Immunoglobulin kappa light chain deficiency (IGKCD) MIM:614102

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 6 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Recurrent infections associated with rare immunoglobulin isotypes deficiency

Disease | ImmuneIEDB

Conditions an epitope on IGKC was assayed in.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGKC as an antibody target. Whether an autoantibody or antibody against IGKC could matter depends on whether native IGKC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGKC is annotated at the cell surface, where native IGKC is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGKC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IGKC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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