Seroatlas · Human Serome Atlas

IGHG3

Immunoglobulin heavy constant gamma 3

Also known as: IGHG3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01860
Gene: IGHG3
Canonical length: 446 aa
Protein class: Immunoglobulin genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

OverviewNCBI Gene

No narrative summary is available for IGHG3 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>P01860|IGHG3
     1  ASTKGPSVFP LAPCSRSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
    61  GLYSLSSVVT VPSSSLGTQT YTCNVNHKPS NTKVDKRVEL KTPLGDTTHT CPRCPEPKSC
   121  DTPPPCPRCP EPKSCDTPPP CPRCPEPKSC DTPPPCPRCP APELLGGPSV FLFPPKPKDT
   181  LMISRTPEVT CVVVDVSHED PEVQFKWYVD GVEVHNAKTK PREEQYNSTF RVVSVLTVLH
   241  QDWLNGKEYK CKVSNKALPA PIEKTISKTK GQPREPQVYT LPPSREEMTK NQVSLTCLVK
   301  GFYPSDIAVE WESSGQPENN YNTTPPMLDS DGSFFLYSKL TVDKSRWQQG NIFSCSVMHE
   361  ALHNRFTQKS LSLSPELQLE ESCAEAQDGE LDGLWTTITI FITLFLLSVC YSATVTFFKV
   421  KWIFSSVVDL KQTIIPDYRN MIGQGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 1,227 nTPM

Expression across tissuesHPA

Tissue

spleen: 1,227 nTPM
tonsil: 872 nTPM
lymph node: 322 nTPM
lung: 181 nTPM
small intestine: 99 nTPM
thyroid gland: 94 nTPM

Single-cell type

plasma cells: 329 nCPM
b-cells: 5.6 nCPM
renal connecting tubule cells: 3.2 nCPM
podocytes: 2.3 nCPM
proximal tubule cells: 1.9 nCPM
parietal cells: 1.8 nCPM

Immune cell

memory B-cell: 212 nTPM
naive B-cell: 65 nTPM
total PBMC: 21 nTPM
neutrophil: 0.3 nTPM
eosinophil: 0.1 nTPM
basophil: 0 nTPM

Brain region

medulla oblongata: 5.4 nTPM
cerebral cortex: 2.8 nTPM
spinal cord: 2.4 nTPM
choroid plexus: 1.9 nTPM
white matter: 1.6 nTPM
hypothalamus: 1.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGHG3.

Disease | ImmuneIEDB

Conditions an epitope on IGHG3 was assayed in.

rheumatoid arthritis B cell
COVID-19 B cell

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGHG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHG3 as an antibody target. Whether an autoantibody or antibody against IGHG3 could matter depends on whether native IGHG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHG3 is annotated at the cell surface, where native IGHG3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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