Seroatlas · Human Serome Atlas

IGHG4

Immunoglobulin heavy constant gamma 4

Also known as: IGHG4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01861
Gene: IGHG4
Ensembl: ENSG00000211892
Chromosome: 14
Canonical length: 396 aa
Protein class: FDA approved drug targets, Immunoglobulin genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

396 residues, UniProt reviewed canonical sequence.

>P01861|IGHG4
     1  ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
    61  GLYSLSSVVT VPSSSLGTKT YTCNVDHKPS NTKVDKRVES KYGPPCPSCP APEFLGGPSV
   121  FLFPPKPKDT LMISRTPEVT CVVVDVSQED PEVQFNWYVD GVEVHNAKTK PREEQFNSTY
   181  RVVSVLTVLH QDWLNGKEYK CKVSNKGLPS SIEKTISKAK GQPREPQVYT LPPSQEEMTK
   241  NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSRL TVDKSRWQEG
   301  NVFSCSVMHE ALHNHYTQKS LSLSLELQLE ESCAEAQDGE LDGLWTTITI FITLFLLSVC
   361  YSATVTFFKV KWIFSSVVDL KQTIVPDYRN MIRQGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 2,338 nTPM

Expression across tissuesHPA

Tissue

appendix: 2,338 nTPM
spleen: 825 nTPM
tonsil: 819 nTPM
urinary bladder: 554 nTPM
esophagus: 376 nTPM
thyroid gland: 320 nTPM

Single-cell type

plasma cells: 120 nCPM
lymphatic endothelial cells: 16 nCPM
b-cells: 1.9 nCPM
mesothelial cells: 1.3 nCPM
mucous neck cells: 0.8 nCPM
foveolar cells: 0.6 nCPM

Immune cell

memory B-cell: 123 nTPM
naive B-cell: 74 nTPM
total PBMC: 20 nTPM
neutrophil: 0.2 nTPM
eosinophil: 0.1 nTPM
myeloid DC: 0.1 nTPM

Brain region

pons: 2.3 nTPM
spinal cord: 1.9 nTPM
cerebral cortex: 1 nTPM
medulla oblongata: 0.9 nTPM
basal ganglia: 0.8 nTPM
cerebellum: 0.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGHG4.

Disease | ImmuneIEDB

Conditions an epitope on IGHG4 was assayed in.

rheumatoid arthritis B and T cell
colonic benign neoplasm T cell

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHG4 as an antibody target. Whether an autoantibody or antibody against IGHG4 could matter depends on whether native IGHG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHG4 is annotated at the cell surface, where native IGHG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Predicted to be involved in antibacterial humoral response and complement activation, classical pathway.

Loading the interactive Seroatlas protein explorer...