Seroatlas · Human Serome Atlas

IGHG1

Immunoglobulin heavy constant gamma 1

Also known as: IGHG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01857
Gene: IGHG1
Ensembl: ENSG00000211896
Chromosome: 14
Canonical length: 399 aa
Protein class: Disease related genes, FDA approved drug targets, Immunoglobulin genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Enables Fc-gamma receptor I complex binding activity. Involved in antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity. Located in extracellular space. Part of IgG immunoglobulin complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>P01857|IGHG1
     1  ASTKGPSVFP LAPSSKSTSG GTAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
    61  GLYSLSSVVT VPSSSLGTQT YICNVNHKPS NTKVDKKVEP KSCDKTHTCP PCPAPELLGG
   121  PSVFLFPPKP KDTLMISRTP EVTCVVVDVS HEDPEVKFNW YVDGVEVHNA KTKPREEQYN
   181  STYRVVSVLT VLHQDWLNGK EYKCKVSNKA LPAPIEKTIS KAKGQPREPQ VYTLPPSRDE
   241  LTKNQVSLTC LVKGFYPSDI AVEWESNGQP ENNYKTTPPV LDSDGSFFLY SKLTVDKSRW
   301  QQGNVFSCSV MHEALHNHYT QKSLSLSPEL QLEESCAEAQ DGELDGLWTT ITIFITLFLL
   361  SVCYSATVTF FKVKWIFSSV VDLKQTIIPD YRNMIGQGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 10,951 nTPM

Expression across tissuesHPA

Tissue

spleen: 10,951 nTPM
tonsil: 5,459 nTPM
urinary bladder: 3,756 nTPM
lymph node: 3,080 nTPM
thymus: 1,659 nTPM
appendix: 1,566 nTPM

Single-cell type

plasma cells: 2,491 nCPM
b-cells: 53 nCPM
platelets: 14 nCPM
parietal cells: 8.8 nCPM
vascular endothelial cells: 7.1 nCPM
foveolar cells: 5.8 nCPM

Immune cell

memory B-cell: 769 nTPM
naive B-cell: 136 nTPM
total PBMC: 96 nTPM
neutrophil: 6.3 nTPM
memory CD4 T-cell: 0.6 nTPM
myeloid DC: 0.4 nTPM

Brain region

spinal cord: 18 nTPM
medulla oblongata: 9.5 nTPM
cerebral cortex: 8.6 nTPM
choroid plexus: 5 nTPM
midbrain: 4.6 nTPM
pons: 3.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGHG1.

Disease | AllUniProt

Conditions IGHG1 is implicated in, by any mechanism.

Multiple myeloma (MM) MIM:254500

Disease | ImmuneIEDB

Conditions an epitope on IGHG1 was assayed in.

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGHG1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHG1 as an antibody target. Whether an autoantibody or antibody against IGHG1 could matter depends on whether native IGHG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHG1 is annotated at the cell surface, where native IGHG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Involved in antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity.

Loading the interactive Seroatlas protein explorer...