IGHD
Immunoglobulin heavy constant delta
Also known as: IGHD_HUMAN
Protein identityUniProt · HPA
- UniProt accession
- P01880
- Gene
- IGHD
- Canonical length
- 430 aa
- Protein class
- Immunoglobulin genes, Predicted membrane proteins
OverviewNCBI Gene
No narrative summary is available for IGHD in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
430 residues, UniProt reviewed canonical sequence.
>P01880|IGHD
1 APTKAPDVFP IISGCRHPKD NSPVVLACLI TGYHPTSVTV TWYMGTQSQP QRTFPEIQRR
61 DSYYMTSSQL STPLQQWRQG EYKCVVQHTA SKSKKEIFRW PESPKAQASS VPTAQPQAEG
121 SLAKATTAPA TTRNTGRGGE EKKKEKEKEE QEERETKTPE CPSHTQPLGV YLLTPAVQDL
181 WLRDKATFTC FVVGSDLKDA HLTWEVAGKV PTGGVEEGLL ERHSNGSQSQ HSRLTLPRSL
241 WNAGTSVTCT LNHPSLPPQR LMALREPAAQ APVKLSLNLL ASSDPPEAAS WLLCEVSGFS
301 PPNILLMWLE DQREVNTSGF APARPPPQPR STTFWAWSVL RVPAPPSPQP ATYTCVVSHE
361 DSRTLLNASR SLEVSYLAMT PLIPQSKDEN SDDYTTFDDV GSLWTTLSTF VALFILTLLY
421 SGIVTFIKVKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against IGHD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Highest tissue expression
- 110 nTPM
Expression across tissuesHPA
Tissue
- tonsil: 110 nTPM
- spleen: 106 nTPM
- salivary gland: 74 nTPM
- lymph node: 53 nTPM
- lung: 29 nTPM
- small intestine: 22 nTPM
Single-cell type
- plasma cells: 1,546 nCPM
- b-cells: 79 nCPM
- innate lymphoid cells: 3.8 nCPM
- thymocytes: 3.4 nCPM
- gastric chief cells: 2.2 nCPM
- erythrocytes: 1.5 nCPM
Immune cell
- naive B-cell: 464 nTPM
- memory B-cell: 147 nTPM
- total PBMC: 20 nTPM
- plasmacytoid DC: 4.9 nTPM
- neutrophil: 1.5 nTPM
- basophil: 1.1 nTPM
Brain region
- cerebral cortex: 0.2 nTPM
- medulla oblongata: 0.1 nTPM
- amygdala: 0 nTPM
- basal ganglia: 0 nTPM
- cerebellum: 0 nTPM
- choroid plexus: 0 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about IGHD.
Disease | ImmuneIEDB
Conditions an epitope on IGHD was assayed in.
- rheumatoid arthritis B cell
OntologyGO
Biological processes
- adaptive immune response
- antibacterial humoral response
- B cell receptor signaling pathway
- complement activation, classical pathway
- immune response
- positive regulation of interleukin-1 production
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Immunoglobulin/major histocompatibility complex, conserved site
- Immunoglobulin C1-set
- Immunoglobulin-like domain
- Immunoglobulin-like beta-sandwich domain
- Immunoglobulin-like fold
- Immunoglobulin-like domain superfamily
- Immune Recognition and Response Modulators
- Immunoglobulin domain
- Immunoglobulin C1-set domain
- Immunoglobulin delta heavy chain-like, delta linker region
- Immunoglobulin D, delta linker region
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of IGHD in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IGHD as an antibody target. Whether an autoantibody or antibody against IGHD could matter depends on whether native IGHD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IGHD is annotated at the cell surface, where native IGHD is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label IGHD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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