TAPBPL

Protein identityUniProt · HPA

UniProt accession

Q9BX59

Gene

TAPBPL

Ensembl

ENSG00000139192

Chromosome

12

Canonical length

468 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Tapasin, or TAPBP (MIM 601962), is a member of the variable-constant Ig superfamily that links major histocompatibility complex (MHC) class I molecules to the transporter associated with antigen processing (TAP; see MIM 170260) in the endoplasmic reticulum (ER). The TAPBP gene is located near the MHC complex on chromosome 6p21.3. TAPBPL is a member of the Ig superfamily that is localized on chromosome 12p13.3, a region somewhat paralogous to the MHC.[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

468 residues, UniProt reviewed canonical sequence.

>Q9BX59|TAPBPL
     1  MGTQEGWCLL LCLALSGAAE TKPHPAEGQW RAVDVVLDCF LAKDGAHRGA LASSEDRARA
    61  SLVLKQVPVL DDGSLEDFTD FQGGTLAQDD PPIIFEASVD LVQIPQAEAL LHADCSGKEV
   121  TCEISRYFLQ MTETTVKTAA WFMANMQVSG GGPSISLVMK TPRVTKNEAL WHPTLNLPLS
   181  PQGTVRTAVE FQVMTQTQSL SFLLGSSASL DCGFSMAPGL DLISVEWRLQ HKGRGQLVYS
   241  WTAGQGQAVR KGATLEPAQL GMARDASLTL PGLTIQDEGT YICQITTSLY RAQQIIQLNI
   301  QASPKVRLSL ANEALLPTLI CDIAGYYPLD VVVTWTREEL GGSPAQVSGA SFSSLRQSVA
   361  GTYSISSSLT AEPGSAGATY TCQVTHISLE EPLGASTQVV PPERRTALGV IFASSLFLLA
   421  LMFLGLQRRQ APTGLGLLQA ERWETTSCAD TQSSHLHEDR TARVSQPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAPBPL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

32 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.22

gnomAD pLI

0

gnomAD missense Z

0.78

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• peptide antigen assembly with MHC class I protein complex
• negative regulation of antigen processing and presentation of peptide antigen via MHC class I

Molecular functions

• MHC class I protein complex binding
• TAP complex binding

Cellular components

• endoplasmic reticulum
• Golgi membrane
• MHC class I peptide loading complex
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin/major histocompatibility complex, conserved site
• Immunoglobulin C1-set
• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• Immune Recognition and Response Modulators
• Immunoglobulin C1-set domain
• Immunoglobulin V-set domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Endoplasmic reticulum
• Golgi apparatus
• Immunity
• Immunoglobulin domain
• Membrane
• Microsome
• Repeat
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of TAPBPL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MR1
• HLA-B
• HLA-C
• HLA-A