Seroatlas · Human Serome Atlas

IGHG2

Immunoglobulin heavy constant gamma 2

Also known as: IGHG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01859
Gene: IGHG2
Ensembl: ENSG00000211893
Chromosome: 14
Canonical length: 395 aa
Protein class: FDA approved drug targets, Immunoglobulin genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in antibacterial humoral response and complement activation, classical pathway. Located in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

395 residues, UniProt reviewed canonical sequence.

>P01859|IGHG2
     1  ASTKGPSVFP LAPCSRSTSE STAALGCLVK DYFPEPVTVS WNSGALTSGV HTFPAVLQSS
    61  GLYSLSSVVT VPSSNFGTQT YTCNVDHKPS NTKVDKTVER KCCVECPPCP APPVAGPSVF
   121  LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVQFNWYVDG VEVHNAKTKP REEQFNSTFR
   181  VVSVLTVVHQ DWLNGKEYKC KVSNKGLPAP IEKTISKTKG QPREPQVYTL PPSREEMTKN
   241  QVSLTCLVKG FYPSDISVEW ESNGQPENNY KTTPPMLDSD GSFFLYSKLT VDKSRWQQGN
   301  VFSCSVMHEA LHNHYTQKSL SLSPELQLEE SCAEAQDGEL DGLWTTITIF ITLFLLSVCY
   361  SATITFFKVK WIFSSVVDLK QTIVPDYRNM IRQGA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 4,046 nTPM

Expression across tissuesHPA

Tissue

spleen: 4,046 nTPM
small intestine: 322 nTPM
colon: 207 nTPM
thyroid gland: 206 nTPM
salivary gland: 200 nTPM
tonsil: 183 nTPM

Single-cell type

plasma cells: 1,010 nCPM
b-cells: 31 nCPM
erythrocytes: 7.4 nCPM
kupffer cells: 2 nCPM
vascular endothelial cells: 1.6 nCPM
neutrophils: 1.5 nCPM

Immune cell

memory B-cell: 345 nTPM
naive B-cell: 129 nTPM
total PBMC: 34 nTPM
memory CD4 T-cell: 0.5 nTPM
MAIT T-cell: 0.4 nTPM
myeloid DC: 0.4 nTPM

Brain region

cerebral cortex: 5.1 nTPM
white matter: 2.6 nTPM
spinal cord: 2.3 nTPM
basal ganglia: 2 nTPM
amygdala: 1.9 nTPM
hypothalamus: 1.5 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGHG2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 1 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Decreased circulating IgG2 concentration

Disease | ImmuneIEDB

Conditions an epitope on IGHG2 was assayed in.

rheumatoid arthritis B cell

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGHG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHG2 as an antibody target. Whether an autoantibody or antibody against IGHG2 could matter depends on whether native IGHG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHG2 is annotated at the cell surface, where native IGHG2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

Predicted to be involved in antibacterial humoral response and complement activation, classical pathway.

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