Seroatlas · Human Serome Atlas

TRBC2

T cell receptor beta constant 2

Also known as: TCRBC2, TRBC2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A0A5B9
Gene: TRBC2
Ensembl: ENSG00000211772
Chromosome: 7
Canonical length: 178 aa
Protein class: Predicted membrane proteins, T-cell receptor genes
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to be involved in T cell receptor signaling pathway; adaptive immune response; and alpha-beta T cell activation. Located in plasma membrane. Part of alpha-beta T cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>A0A5B9|TRBC2
     1  DLKNVFPPKV AVFEPSEAEI SHTQKATLVC LATGFYPDHV ELSWWVNGKE VHSGVSTDPQ
    61  PLKEQPALND SRYCLSSRLR VSATFWQNPR NHFRCQVQFY GLSENDEWTQ DRAKPVTQIV
   121  SAEAWGRADC GFTSESYQQG VLSATILYEI LLGKATLYAV LVSALVLMAM VKRKDSRG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TRBC2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 181 nTPM

Expression across tissuesHPA

Tissue

spleen: 181 nTPM
small intestine: 107 nTPM
thymus: 102 nTPM
lung: 31 nTPM
colon: 22 nTPM
adipose tissue: 18 nTPM

Single-cell type

t-cells: 293 nCPM
nk-cells: 90 nCPM
innate lymphoid cells: 59 nCPM
b-cells: 54 nCPM
peritubular myoid cells: 45 nCPM
leydig cells: 38 nCPM

Immune cell

T-reg: 76 nTPM
memory CD4 T-cell: 48 nTPM
memory CD8 T-cell: 47 nTPM
naive CD4 T-cell: 47 nTPM
total PBMC: 42 nTPM
naive CD8 T-cell: 40 nTPM

Brain region

cerebral cortex: 0.9 nTPM
basal ganglia: 0.7 nTPM
thalamus: 0.7 nTPM
midbrain: 0.6 nTPM
hippocampal formation: 0.5 nTPM
medulla oblongata: 0.5 nTPM

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TRBC2 as an antibody target. Whether an autoantibody or antibody against TRBC2 could matter depends on whether native TRBC2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TRBC2 is annotated at the cell surface, where native TRBC2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TRBC2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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