Seroatlas · Human Serome Atlas

IGHE

Immunoglobulin heavy constant epsilon

Also known as: IGHE_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P01854
Gene: IGHE
Ensembl: ENSG00000211891
Chromosome: 14
Canonical length: 546 aa
Protein class: Immunoglobulin genes, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins
Secretome location: Immunoglobulin genes

OverviewNCBI Gene

Enables immunoglobulin receptor binding activity. Involved in several processes, including B cell mediated immunity; Fc receptor-mediated immune complex endocytosis; and leukocyte degranulation. Located in extracellular space and plasma membrane. Part of IgE B cell receptor complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

546 residues, UniProt reviewed canonical sequence.

>P01854|IGHE
     1  ASTQSPSVFP LTRCCKNIPS NATSVTLGCL ATGYFPEPVM VTWDTGSLNG TTMTLPATTL
    61  TLSGHYATIS LLTVSGAWAK QMFTCRVAHT PSSTDWVDNK TFSVCSRDFT PPTVKILQSS
   121  CDGGGHFPPT IQLLCLVSGY TPGTINITWL EDGQVMDVDL STASTTQEGE LASTQSELTL
   181  SQKHWLSDRT YTCQVTYQGH TFEDSTKKCA DSNPRGVSAY LSRPSPFDLF IRKSPTITCL
   241  VVDLAPSKGT VNLTWSRASG KPVNHSTRKE EKQRNGTLTV TSTLPVGTRD WIEGETYQCR
   301  VTHPHLPRAL MRSTTKTSGP RAAPEVYAFA TPEWPGSRDK RTLACLIQNF MPEDISVQWL
   361  HNEVQLPDAR HSTTQPRKTK GSGFFVFSRL EVTRAEWEQK DEFICRAVHE AASPSQTVQR
   421  AVSVNPGLAG GSAQSQRAPD RVLCHSGQQQ GLPRAAGGSV PHPRCHCGAG RADWPGPPEL
   481  DVCVEEAEGE APWTWTGLCI FAALFLLSVS YSAAITLLMV QRFLSATRQG RPQTSLDYTN
   541  VLQPHA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGHE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Highest tissue expression: 4.4 nTPM

Expression across tissuesHPA

Tissue

spleen: 4.4 nTPM
thyroid gland: 2.5 nTPM
small intestine: 1.7 nTPM
stomach: 1.4 nTPM
colon: 1 nTPM
adipose tissue: 0.7 nTPM

Single-cell type

oocytes: 23 nCPM
epididymal principal cells: 8.4 nCPM
plasma cells: 3.5 nCPM
b-cells: 0.3 nCPM
esophageal apical cells: 0.1 nCPM
adipocytes: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IGHE.

Disease | ImmuneIEDB

Conditions an epitope on IGHE was assayed in.

rheumatoid arthritis B cell

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IGHE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FCER1A

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IGHE as an antibody target. Whether an autoantibody or antibody against IGHE could matter depends on whether native IGHE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IGHE is annotated at the cell surface, where native IGHE is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IGHE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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