Proton-linked Monocarboxylate Transporter
IPR050327
Definition
The Monocarboxylate Transporter (MCT) family comprises proteins that facilitate the proton-linked transport of monocarboxylates across the plasma membrane [[cite:PMID:32415067], [cite:PMID:31784090]]. Members of this family play diverse roles in the transport of metabolites such as lactate, pyruvate, ketone bodies, and thyroid hormones, contributing to various physiological processes including pH regulation, metabolic homeostasis, and hormone distribution [[cite:PMID:11827462], [cite:PMID:18337592], [cite:PMID:28754537]]. Some family members are also involved in the efflux of specific metabolites and secondary metabolites, including mycotoxins and antibiotics, in various organisms. The transport mechanism often involves symport or antiport with protons and is typically regulated by substrate concentration, pH, and other factors. The MCT family is part of the major facilitator superfamily (MFS) and is characterised by a common structural framework that facilitates the transport activity.
14 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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