Seroatlas · Human Serome Atlas

SLC16A6

Monocarboxylate transporter 7

Also known as: MCT6, MCT7, MOT7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15403
Gene
SLC16A6
Ensembl
ENSG00000108932
Chromosome
17
Canonical length
523 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be located in basolateral plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

523 residues, UniProt reviewed canonical sequence.

>O15403|SLC16A6
     1  MTQNKLKLCS KANVYTEVPD GGWGWAVAVS FFFVEVFTYG IIKTFGVFFN DLMDSFNESN
    61  SRISWIISIC VFVLTFSAPL ATVLSNRFGH RLVVMLGGLL VSTGMVAASF SQEVSHMYVA
   121  IGIISGLGYC FSFLPTVTIL SQYFGKRRSI VTAVASTGEC FAVFAFAPAI MALKERIGWR
   181  YSLLFVGLLQ LNIVIFGALL RPIFIRGPAS PKIVIQENRK EAQYMLENEK TRTSIDSIDS
   241  GVELTTSPKN VPTHTNLELE PKADMQQVLV KTSPRPSEKK APLLDFSILK EKSFICYALF
   301  GLFATLGFFA PSLYIIPLGI SLGIDQDRAA FLLSTMAIAE VFGRIGAGFV LNREPIRKIY
   361  IELICVILLT VSLFAFTFAT EFWGLMSCSI FFGFMVGTIG GTHIPLLAED DVVGIEKMSS
   421  AAGVYIFIQS IAGLAGPPLA GLLVDQSKIY SRAFYSCAAG MALAAVCLAL VRPCKMGLCQ
   481  HHHSGETKVV SHRGKTLQDI PEDFLEMDLA KNEHRVHVQM EPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
43 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 43 nTPM
  • epididymis: 31 nTPM
  • retina: 28 nTPM
  • esophagus: 10 nTPM
  • bone marrow: 9.2 nTPM
  • appendix: 6.8 nTPM

Single-cell type

  • monocytes: 276 nCPM
  • choroid plexus epithelial cells: 168 nCPM
  • neutrophils: 159 nCPM
  • endometrial glandular cells: 101 nCPM
  • epididymal principal cells: 93 nCPM
  • rod photoreceptor cells: 60 nCPM

Immune cell

  • neutrophil: 4.5 nTPM
  • classical monocyte: 2.5 nTPM
  • intermediate monocyte: 2.3 nTPM
  • gdT-cell: 1.6 nTPM
  • myeloid DC: 1.5 nTPM
  • T-reg: 1.3 nTPM

Brain region

  • choroid plexus: 108 nTPM
  • thalamus: 16 nTPM
  • hypothalamus: 16 nTPM
  • pons: 16 nTPM
  • hippocampal formation: 15 nTPM
  • basal ganglia: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.84
gnomAD pLI
0
gnomAD missense Z
1.84
DepMap mean gene effect
-0.21
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC16A6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A6 as an antibody target. Whether an autoantibody or antibody against SLC16A6 could matter depends on whether native SLC16A6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A6 is annotated at the cell surface, where native SLC16A6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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