Seroatlas · Human Serome Atlas

SLC16A3

Monocarboxylate transporter 4

Also known as: MCT3, MCT4, MOT4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O15427
Gene
SLC16A3
Ensembl
ENSG00000141526
Chromosome
17
Canonical length
465 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Nuclear membrane,Plasma membrane

OverviewNCBI Gene

Lactic acid and pyruvate transport across plasma membranes is catalyzed by members of the proton-linked monocarboxylate transporter (MCT) family, which has been designated solute carrier family-16. Each MCT appears to have slightly different substrate and inhibitor specificities and transport kinetics, which are related to the metabolic requirements of the tissues in which it is found. The MCTs, which include MCT1 (SLC16A1; MIM 600682) and MCT2 (SLC16A7; MIM 603654), are characterized by 12 predicted transmembrane domains (Price et al., 1998 [PubMed 9425115]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>O15427|SLC16A3
     1  MGGAVVDEGP TGVKAPDGGW GWAVLFGCFV ITGFSYAFPK AVSVFFKELI QEFGIGYSDT
    61  AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLVGGLFASL GMVAASFCRS IIQVYLTTGV
   121  ITGLGLALNF QPSLIMLNRY FSKRRPMANG LAAAGSPVFL CALSPLGQLL QDRYGWRGGF
   181  LILGGLLLNC CVCAALMRPL VVTAQPGSGP PRPSRRLLDL SVFRDRGFVL YAVAASVMVL
   241  GLFVPPVFVV SYAKDLGVPD TKAAFLLTIL GFIDIFARPA AGFVAGLGKV RPYSVYLFSF
   301  SMFFNGLADL AGSTAGDYGG LVVFCIFFGI SYGMVGALQF EVLMAIVGTH KFSSAIGLVL
   361  LMEAVAVLVG PPSGGKLLDA THVYMYVFIL AGAEVLTSSL ILLLGNFFCI RKKPKEPQPE
   421  VAAAEEEKLH KPPADSGVDL REVEHFLKAE PEKNGEVVHT PETSV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
134 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 134 nTPM
  • tongue: 68 nTPM
  • spleen: 40 nTPM
  • lung: 33 nTPM
  • esophagus: 29 nTPM
  • blood vessel: 29 nTPM

Single-cell type

  • extravillous trophoblasts: 2,421 nCPM
  • syncytiotrophoblasts: 885 nCPM
  • neutrophils: 850 nCPM
  • retinal pigment epithelial cells: 661 nCPM
  • esophageal apical cells: 585 nCPM
  • epicardial cells: 380 nCPM

Immune cell

  • neutrophil: 110 nTPM
  • eosinophil: 92 nTPM
  • basophil: 57 nTPM
  • classical monocyte: 33 nTPM
  • non-classical monocyte: 32 nTPM
  • intermediate monocyte: 31 nTPM

Brain region

  • medulla oblongata: 43 nTPM
  • white matter: 37 nTPM
  • thalamus: 36 nTPM
  • pons: 31 nTPM
  • cerebral cortex: 27 nTPM
  • spinal cord: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
-0.05
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC16A3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A3 as an antibody target. Whether an autoantibody or antibody against SLC16A3 could matter depends on whether native SLC16A3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A3 is annotated at the cell surface, where native SLC16A3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...