Seroatlas · Human Serome Atlas

SLC16A1

Monocarboxylate transporter 1

Also known as: MCT, MCT1, MOT1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P53985
Gene
SLC16A1
Ensembl
ENSG00000155380
Chromosome
1
Canonical length
500 aa
Protein class
Disease related genes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Plasma membrane,Cell Junctions

OverviewNCBI Gene

The protein encoded by this gene is a proton-linked monocarboxylate transporter that catalyzes the movement of many monocarboxylates, such as lactate and pyruvate, across the plasma membrane. Mutations in this gene are associated with erythrocyte lactate transporter defect. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

500 residues, UniProt reviewed canonical sequence.

>P53985|SLC16A1
     1  MPPAVGGPVG YTPPDGGWGW AVVIGAFISI GFSYAFPKSI TVFFKEIEGI FHATTSEVSW
    61  ISSIMLAVMY GGGPISSILV NKYGSRIVMI VGGCLSGCGL IAASFCNTVQ QLYVCIGVIG
   121  GLGLAFNLNP ALTMIGKYFY KRRPLANGLA MAGSPVFLCT LAPLNQVFFG IFGWRGSFLI
   181  LGGLLLNCCV AGALMRPIGP KPTKAGKDKS KASLEKAGKS GVKKDLHDAN TDLIGRHPKQ
   241  EKRSVFQTIN QFLDLTLFTH RGFLLYLSGN VIMFFGLFAP LVFLSSYGKS QHYSSEKSAF
   301  LLSILAFVDM VARPSMGLVA NTKPIRPRIQ YFFAASVVAN GVCHMLAPLS TTYVGFCVYA
   361  GFFGFAFGWL SSVLFETLMD LVGPQRFSSA VGLVTIVECC PVLLGPPLLG RLNDMYGDYK
   421  YTYWACGVVL IISGIYLFIG MGINYRLLAK EQKANEQKKE SKEEETSIDV AGKPNEVTKA
   481  AESPDQKDTD GGPKEEESPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • retina: 64 nTPM
  • heart muscle: 64 nTPM
  • skeletal muscle: 63 nTPM
  • tongue: 56 nTPM
  • liver: 52 nTPM
  • colon: 44 nTPM

Single-cell type

  • late spermatids: 58 nCPM
  • müller glia: 56 nCPM
  • choroid plexus epithelial cells: 55 nCPM
  • ependymal cells: 50 nCPM
  • early spermatids: 46 nCPM
  • retinal pigment epithelial cells: 38 nCPM

Immune cell

  • T-reg: 6.2 nTPM
  • myeloid DC: 2.5 nTPM
  • memory CD8 T-cell: 2 nTPM
  • memory CD4 T-cell: 1.8 nTPM
  • MAIT T-cell: 1.7 nTPM
  • intermediate monocyte: 1.6 nTPM

Brain region

  • medulla oblongata: 33 nTPM
  • thalamus: 31 nTPM
  • white matter: 31 nTPM
  • choroid plexus: 30 nTPM
  • cerebellum: 30 nTPM
  • spinal cord: 29 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC16A1.

Disease | AllUniProt

Conditions SLC16A1 is implicated in, by any mechanism.

  • Symptomatic deficiency in lactate transport (SDLT) MIM:245340
  • Hyperinsulinemic hypoglycemia, familial, 7 (HHF7) MIM:610021
  • Monocarboxylate transporter 1 deficiency (MCT1D) MIM:616095

Disease | GeneticClinVar

23 pathogenic / likely-pathogenic of 365 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Ketoacidosis due to monocarboxylate transporter-1 deficiency
  • Exercise-induced hyperinsulinism
  • Monocarboxylate transporter 1 deficiency, autosomal dominant
  • SLC16A1-related disorder
  • Monocarboxylate transporter 1 deficiency, autosomal recessive

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0
gnomAD missense Z
1.65
DepMap mean gene effect
-0.27
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC16A1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A1 as an antibody target. Whether an autoantibody or antibody against SLC16A1 could matter depends on whether native SLC16A1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A1 is annotated at the cell surface, where native SLC16A1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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