Seroatlas · Human Serome Atlas

SLC16A11

Monocarboxylate transporter 11

Also known as: MOT11_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NCK7
Gene
SLC16A11
Canonical length
471 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

No narrative summary is available for SLC16A11 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

471 residues, UniProt reviewed canonical sequence.

>Q8NCK7|SLC16A11
     1  MPAPQRKHRR GGFSHRCFPT PQTAMTPQPA GPPDGGWGWV VAAAAFAING LSYGLLRSLG
    61  LAFPDLAEHF DRSAQDTAWI SALALAVQQA ASPVGSALST RWGARPVVMV GGVLASLGFV
   121  FSAFASDLLH LYLGLGLLAG FGWALVFAPA LGTLSRYFSR RRVLAVGLAL TGNGASSLLL
   181  APALQLLLDT FGWRGALLLL GAITLHLTPC GALLLPLVLP GDPPAPPRSP LAALGLSLFT
   241  RRAFSIFALG TALVGGGYFV PYVHLAPHAL DRGLGGYGAA LVVAVAAMGD AGARLVCGWL
   301  ADQGWVPLPR LLAVFGALTG LGLWVVGLVP VVGGEESWGG PLLAAAVAYG LSAGSYAPLV
   361  FGVLPGLVGV GGVVQATGLV MMLMSLGGLL GPPLSGFLRD ETGDFTASFL LSGSLILSGS
   421  FIYIGLPRAL PSCGPASPPA TPPPETGELL PAPQAVLLSP GGPGSTLDTT C

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
11
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 12 nTPM
  • thyroid gland: 9.8 nTPM
  • liver: 7.5 nTPM
  • salivary gland: 7.1 nTPM
  • fallopian tube: 5.5 nTPM
  • parathyroid gland: 5.1 nTPM

Single-cell type

  • fallopian tube ciliated cells: 92 nCPM
  • epididymal clear cells: 53 nCPM
  • müller glia: 28 nCPM
  • tuft cells: 23 nCPM
  • epididymal efferent duct absorptive cells: 22 nCPM
  • epididymal principal cells: 22 nCPM

Immune cell

  • gdT-cell: 1.5 nTPM
  • memory CD8 T-cell: 1.4 nTPM
  • naive CD8 T-cell: 1.3 nTPM
  • naive B-cell: 1 nTPM
  • MAIT T-cell: 0.9 nTPM
  • naive CD4 T-cell: 0.7 nTPM

Brain region

  • choroid plexus: 15 nTPM
  • cerebellum: 4.9 nTPM
  • spinal cord: 4.6 nTPM
  • medulla oblongata: 4.5 nTPM
  • hypothalamus: 4.4 nTPM
  • midbrain: 3.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC16A11.

Disease | AllUniProt

Conditions SLC16A11 is implicated in, by any mechanism.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.44
gnomAD pLI
0
gnomAD missense Z
0.38
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC16A11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A11 as an antibody target. Whether an autoantibody or antibody against SLC16A11 could matter depends on whether native SLC16A11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A11 is annotated at the cell surface, where native SLC16A11 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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