Seroatlas · Human Serome Atlas

SLC16A9

Monocarboxylate transporter 9

Also known as: C10orf36, FLJ43803, MCT9, MOT9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7RTY1
Gene
SLC16A9
Ensembl
ENSG00000165449
Chromosome
10
Canonical length
509 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Cell Junctions

OverviewNCBI Gene

Enables carnitine transmembrane transporter activity and creatine transmembrane transporter activity. Involved in carnitine transmembrane transport; creatine transmembrane transport; and urate metabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

509 residues, UniProt reviewed canonical sequence.

>Q7RTY1|SLC16A9
     1  MELKKSPDGG WGWVIVFVSF LTQFLCYGSP LAVGVLYIEW LDAFGEGKGK TAWVGSLASG
    61  VGLLASPVCS LCVSSFGARP VTIFSGFMVA GGLMLSSFAP NIYFLFFSYG IVVGLGCGLL
   121  YTATVTITCQ YFDDRRGLAL GLISTGSSVG LFIYAALQRM LVEFYGLDGC LLIVGALALN
   181  ILACGSLMRP LQSSDCPLPK KIAPEDLPDK YSIYNEKGKN LEENINILDK SYSSEEKCRI
   241  TLANGDWKQD SLLHKNPTVT HTKEPETYKK KVAEQTYFCK QLAKRKWQLY KNYCGETVAL
   301  FKNKVFSALF IAILLFDIGG FPPSLLMEDV ARSSNVKEEE FIMPLISIIG IMTAVGKLLL
   361  GILADFKWIN TLYLYVATLI IMGLALCAIP FAKSYVTLAL LSGILGFLTG NWSIFPYVTT
   421  KTVGIEKLAH AYGILMFFAG LGNSLGPPIV GWFYDWTQTY DIAFYFSGFC VLLGGFILLL
   481  AALPSWDTCN KQLPKPAPTT FLYKVASNV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
178 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 178 nTPM
  • adrenal gland: 143 nTPM
  • ovary: 41 nTPM
  • spleen: 38 nTPM
  • parathyroid gland: 27 nTPM
  • fallopian tube: 21 nTPM

Single-cell type

  • proximal tubule cells: 1,103 nCPM
  • adrenal cortex cells: 850 nCPM
  • choroid plexus epithelial cells: 201 nCPM
  • astrocytes: 143 nCPM
  • esophageal apical cells: 119 nCPM
  • colonocytes: 100 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 26 nTPM
  • hypothalamus: 23 nTPM
  • white matter: 19 nTPM
  • medulla oblongata: 17 nTPM
  • midbrain: 17 nTPM
  • spinal cord: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.69
gnomAD pLI
0.01
gnomAD missense Z
0.7
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A9 as an antibody target. Whether an autoantibody or antibody against SLC16A9 could matter depends on whether native SLC16A9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A9 is annotated at the cell surface, where native SLC16A9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A9. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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