Seroatlas · Human Serome Atlas

SLC16A10

Monocarboxylate transporter 10

Also known as: MCT10, MOT10_HUMAN, TAT1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TF71
Gene
SLC16A10
Ensembl
ENSG00000112394
Chromosome
6
Canonical length
515 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Vesicles,Cell Junctions

OverviewNCBI Gene

SLC16A10 is a member of a family of plasma membrane amino acid transporters that mediate the Na(+)-independent transport of aromatic amino acids across the plasma membrane.[supplied by OMIM, Apr 2004]

Canonical amino-acid sequenceUniProt

515 residues, UniProt reviewed canonical sequence.

>Q8TF71|SLC16A10
     1  MVLSQEEPDS ARGTSEAQPL GPAPTGAAPP PGPGPSDSPE AAVEKVEVEL AGPATAEPHE
    61  PPEPPEGGWG WLVMLAAMWC NGSVFGIQNA CGVLFVSMLE TFGSKDDDKM VFKTAWVGSL
   121  SMGMIFFCCP IVSVFTDLFG CRKTAVVGAA VGFVGLMSSS FVSSIEPLYL TYGIIFACGC
   181  SFAYQPSLVI LGHYFKKRLG LVNGIVTAGS SVFTILLPLL LRVLIDSVGL FYTLRVLCIF
   241  MFVLFLAGFT YRPLATSTKD KESGGSGSSL FSRKKFSPPK KIFNFAIFKV TAYAVWAVGI
   301  PLALFGYFVP YVHLMKHVNE RFQDEKNKEV VLMCIGVTSG VGRLLFGRIA DYVPGVKKVY
   361  LQVLSFFFIG LMSMMIPLCS IFGALIAVCL IMGLFDGCFI SIMAPIAFEL VGAQDVSQAI
   421  GFLLGFMSIP MTVGPPIAGL LRDKLGSYDV AFYLAGVPPL IGGAVLCFIP WIHSKKQREI
   481  SKTTGKEKME KMLENQNSLL SSSSGMFKKE SDSII

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 34 nTPM
  • pancreas: 28 nTPM
  • choroid plexus: 25 nTPM
  • placenta: 22 nTPM
  • skin: 14 nTPM
  • liver: 13 nTPM

Single-cell type

  • myonuclei: 1,010 nCPM
  • choroid plexus epithelial cells: 986 nCPM
  • monocytes: 548 nCPM
  • macrophages: 530 nCPM
  • melanocytes: 400 nCPM
  • podocytes: 375 nCPM

Immune cell

  • naive CD4 T-cell: 1.7 nTPM
  • T-reg: 1.6 nTPM
  • naive CD8 T-cell: 1.5 nTPM
  • basophil: 0.4 nTPM
  • memory CD4 T-cell: 0.4 nTPM
  • neutrophil: 0.3 nTPM

Brain region

  • choroid plexus: 87 nTPM
  • basal ganglia: 22 nTPM
  • midbrain: 16 nTPM
  • thalamus: 15 nTPM
  • cerebellum: 13 nTPM
  • cerebral cortex: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.54
gnomAD pLI
0.31
gnomAD missense Z
1.74
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A10 as an antibody target. Whether an autoantibody or antibody against SLC16A10 could matter depends on whether native SLC16A10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A10 is annotated at the cell surface, where native SLC16A10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A10. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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