Seroatlas · Human Serome Atlas

SLC16A5

Monocarboxylate transporter 6

Also known as: MCT5, MCT6, MOT6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15375
Gene: SLC16A5
Ensembl: ENSG00000170190
Chromosome: 17
Canonical length: 505 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters

OverviewNCBI Gene

This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

505 residues, UniProt reviewed canonical sequence.

>O15375|SLC16A5
     1  MPQALERADG SWAWVVLLAT MVTQGLTLGF PTCIGIFFTE LQWEFQASNS ETSWFPSILT
    61  AVLHMAGPLC SILVGRFGCR VTVMLGGVLA SLGMVASSFS HNLSQLYFTA GFITGLGMCF
   121  SFQSSITVLG FYFVRRRVLA NALASMGVSL GITLWPLLSR YLLENLGWRG TFLVFGGIFL
   181  HCCICGAIIR PVATSVAPET KECPPPPPET PALGCLAACG RTIQRHLAFD ILRHNTGYCV
   241  YILGVMWSVL GFPLPQVFLV PYAMWHSVDE QQAALLISII GFSNIFLRPL AGLMAGRPAF
   301  ASHRKYLFSL ALLLNGLTNL VCAASGDFWV LVGYCLAYSV SMSGIGALIF QVLMDIVPMD
   361  QFPRALGLFT VLDGLAFLIS PPLAGLLLDA TNNFSYVFYM SSFFLISAAL FMGGSFYALQ
   421  KKEQGKQAVA ADALERDLFL EAKDGPGKQR SPEIMCQSSR QPRPAGVNKH LWGCPASSRT
   481  SHEWLLWPKA VLQAKQTALG WNSPT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

kidney: 67 nTPM
duodenum: 32 nTPM
stomach: 25 nTPM
lung: 24 nTPM
small intestine: 23 nTPM
urinary bladder: 17 nTPM

Single-cell type

renal collecting duct principal cells: 242 nCPM
renal collecting duct intercalated cells: 143 nCPM
papillary tip epithelial cells: 114 nCPM
loop of henle epithelial cells: 99 nCPM
alveolar cells type 1: 89 nCPM
urothelial cells: 87 nCPM

Immune cell

neutrophil: 35 nTPM
classical monocyte: 13 nTPM
intermediate monocyte: 5 nTPM
total PBMC: 4.4 nTPM
basophil: 4.1 nTPM
myeloid DC: 3.9 nTPM

Brain region

choroid plexus: 10 nTPM
hypothalamus: 4.5 nTPM
medulla oblongata: 4.4 nTPM
midbrain: 4.1 nTPM
thalamus: 4 nTPM
spinal cord: 3.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.52
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

monocarboxylic acid transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A5 as an antibody target. Whether an autoantibody or antibody against SLC16A5 could matter depends on whether native SLC16A5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A5 is annotated at the cell surface, where native SLC16A5 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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