Seroatlas · Human Serome Atlas

SLC16A8

Monocarboxylate transporter 3

Also known as: MCT3, MOT3_HUMAN, REMP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95907
Gene: SLC16A8
Ensembl: ENSG00000100156
Chromosome: 22
Canonical length: 504 aa
Protein class: Metabolic proteins, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Intermediate filaments,Focal adhesion sites

OverviewNCBI Gene

SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>O95907|SLC16A8
     1  MGAGGPRRGE GPPDGGWGWV VLGACFVVTG FAYGFPKAVS VFFRALMRDF DAGYSDTAWV
    61  SSIMLAMLYG TGPVSSILVT RFGCRPVMLA GGLLASAGMI LASFATRLLE LYLTAGVLTG
   121  LGLALNFQPS LIMLGLYFER RRPLANGLAA AGSPVFLSAL SPLGQQLLER FGWRGGFLLL
   181  GGLLLHCCAC GAVMRPPPGP GPRPRRDSAG DRAGDAPGEA EADGAGLQLR EASPRVRPRR
   241  RLLDLAVCTD RAFAVYAVTK FLMALGLFVP AILLVNYAKD AGVPDTDAAF LLSIVGFVDI
   301  VARPACGALA GLARLRPHVP YLFSLALLAN GLTDLSSARA RSYGALVAFC VAFGLSYGMV
   361  GALQFEVLMA AVGAPRFPSA LGLVLLVEAA AVLIGPPSAG RLVDVLKNYE IIFYLAGSEV
   421  ALAGVFMAVA TNCCLRCAKA APSGPGTEGG ASDTEDAEAE GDSEPLPVVA EEPGNLEALE
   481  VLSARGEPTE PEIEARPRLA AESV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 2.4 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 2.4 nTPM
spinal cord: 1.6 nTPM
hypothalamus: 1.4 nTPM
prostate: 1.4 nTPM
blood vessel: 1.3 nTPM
midbrain: 1.3 nTPM

Single-cell type

retinal pigment epithelial cells: 533 nCPM
oocytes: 28 nCPM
undifferentiated spermatogonia: 12 nCPM
schwann cells: 9.2 nCPM
hepatic stellate cells: 6.5 nCPM
other brain neurons: 5.8 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

white matter: 26 nTPM
cerebral cortex: 21 nTPM
medulla oblongata: 16 nTPM
pons: 15 nTPM
basal ganglia: 15 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0.01
gnomAD missense Z: 0.93
DepMap mean gene effect: 0
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

lactate transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A8 as an antibody target. Whether an autoantibody or antibody against SLC16A8 could matter depends on whether native SLC16A8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A8 is annotated at the cell surface, where native SLC16A8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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