Seroatlas · Human Serome Atlas

SLC16A13

Monocarboxylate transporter 13

Also known as: MCT13, MOT13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7RTY0
Gene
SLC16A13
Ensembl
ENSG00000174327
Chromosome
17
Canonical length
426 aa
Protein class
Disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport and transmembrane transport. Located in Golgi apparatus and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

426 residues, UniProt reviewed canonical sequence.

>Q7RTY0|SLC16A13
     1  MARRTEPPDG GWGWVVVLSA FFQSALVFGV LRSFGVFFVE FVAAFEEQAA RVSWIASIGI
    61  AVQQFGSPVG SALSTKFGPR PVVMTGGILA ALGMLLASFA TSLTHLYLSI GLLSGSGWAL
   121  TFAPTLACLS CYFSRRRSLA TGLALTGVGL SSFTFAPFFQ WLLSHYAWRG SLLLVSALSL
   181  HLVACGALLR PPSLAEDPAV GGPRAQLTSL LHHGPFLRYT VALTLINTGY FIPYLHLVAH
   241  LQDLDWDPLP AAFLLSVVAI SDLVGRVVSG WLGDAVPGPV TRLLMLWTTL TGVSLALFPV
   301  AQAPTALVAL AVAYGFTSGA LAPLAFSVLP ELIGTRRIYC GLGLLQMIES IGGLLGPPLS
   361  GYLRDVTGNY TASFVVAGAF LLSGSGILLT LPHFFCFSTT TSGPQDLVTE ALDTKVPLPK
   421  EGLEED

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
34 nTPM

Expression across tissuesHPA

Tissue

  • liver: 34 nTPM
  • duodenum: 8.7 nTPM
  • kidney: 6.4 nTPM
  • small intestine: 5.2 nTPM
  • skin: 5 nTPM
  • esophagus: 4.9 nTPM

Single-cell type

  • paneth cells: 31 nCPM
  • tuft cells: 23 nCPM
  • proximal tubule cells: 19 nCPM
  • enterocytes: 15 nCPM
  • conjunctival goblet cells: 15 nCPM
  • müller glia: 14 nCPM

Immune cell

  • naive B-cell: 2.5 nTPM
  • memory CD8 T-cell: 1.5 nTPM
  • gdT-cell: 1.2 nTPM
  • NK-cell: 1.2 nTPM
  • T-reg: 1.2 nTPM
  • memory B-cell: 1.1 nTPM

Brain region

  • cerebellum: 4.7 nTPM
  • medulla oblongata: 3.4 nTPM
  • midbrain: 3.3 nTPM
  • thalamus: 3.2 nTPM
  • amygdala: 3.1 nTPM
  • cerebral cortex: 3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SLC16A13.

Disease | AllUniProt

Conditions SLC16A13 is implicated in, by any mechanism.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.71
gnomAD pLI
0
gnomAD missense Z
0.18
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A13 as an antibody target. Whether an autoantibody or antibody against SLC16A13 could matter depends on whether native SLC16A13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A13 is annotated at the cell surface, where native SLC16A13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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