Seroatlas · Human Serome Atlas

SLC16A14

Monocarboxylate transporter 14

Also known as: FLJ30794, MCT14, MOT14_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7RTX9
Gene: SLC16A14
Ensembl: ENSG00000163053
Chromosome: 2
Canonical length: 510 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

510 residues, UniProt reviewed canonical sequence.

>Q7RTX9|SLC16A14
     1  MYTSHEDIGY DFEDGPKDKK TLKPHPNIDG GWAWMMVLSS FFVHILIMGS QMALGVLNVE
    61  WLEEFHQSRG LTAWVSSLSM GITLIVGPFI GLFINTCGCR QTAIIGGLVN SLGWVLSAYA
   121  ANVHYLFITF GVAAGLGSGM AYLPAVVMVG RYFQKRRALA QGLSTTGTGF GTFLMTVLLK
   181  YLCAEYGWRN AMLIQGAVSL NLCVCGALMR PLSPGKNPND PGEKDVRGLP AHSTESVKST
   241  GQQGRTEEKD GGLGNEETLC DLQAQECPDQ AGHRKNMCAL RILKTVSWLT MRVRKGFEDW
   301  YSGYFGTASL FTNRMFVAFI FWALFAYSSF VIPFIHLPEI VNLYNLSEQN DVFPLTSIIA
   361  IVHIFGKVIL GVIADLPCIS VWNVFLLANF TLVLSIFILP LMHTYAGLAV ICALIGFSSG
   421  YFSLMPVVTE DLVGIEHLAN AYGIIICANG ISALLGPPFA GWIYDITQKY DFSFYICGLL
   481  YMIGILFLLI QPCIRIIEQS RRKYMDGAHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

salivary gland: 18 nTPM
skin: 10 nTPM
cerebellum: 9.7 nTPM
ovary: 8.4 nTPM
cerebral cortex: 7.4 nTPM
parathyroid gland: 6.6 nTPM

Single-cell type

retinal pigment epithelial cells: 853 nCPM
salivary acinar cells: 65 nCPM
brain inhibitory neurons: 32 nCPM
adrenal cortex cells: 30 nCPM
brain excitatory neurons: 29 nCPM
vascular endothelial cells: 29 nCPM

Immune cell

eosinophil: 11 nTPM
gdT-cell: 0.4 nTPM
myeloid DC: 0.4 nTPM
MAIT T-cell: 0.3 nTPM
memory B-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM

Brain region

thalamus: 27 nTPM
cerebellum: 25 nTPM
amygdala: 23 nTPM
hypothalamus: 22 nTPM
cerebral cortex: 22 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.72
gnomAD pLI: 0.01
gnomAD missense Z: 1.85
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

carboxylic acid transmembrane transport

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A14 as an antibody target. Whether an autoantibody or antibody against SLC16A14 could matter depends on whether native SLC16A14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A14 is annotated at the cell surface, where native SLC16A14 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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