Seroatlas · Human Serome Atlas

SLC16A4

Monocarboxylate transporter 5

Also known as: MCT4, MCT5, MOT5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15374
Gene: SLC16A4
Ensembl: ENSG00000168679
Chromosome: 1
Canonical length: 487 aa
Protein class: Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location: Microtubules,Cytokinetic bridge,Cytosol

OverviewNCBI Gene

Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in carboxylic acid transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

487 residues, UniProt reviewed canonical sequence.

>O15374|SLC16A4
     1  MLKREGKVQP YTKTLDGGWG WMIVIHFFLV NVFVMGMTKT FAIFFVVFQE EFEGTSEQIG
    61  WIGSIMSSLR FCAGPLVAII CDILGEKTTS ILGAFVVTGG YLISSWATSI PFLCVTMGLL
   121  PGLGSAFLYQ VAAVVTTKYF KKRLALSTAI ARSGMGLTFL LAPFTKFLID LYDWTGALIL
   181  FGAIALNLVP SSMLLRPIHI KSENNSGIKD KGSSLSAHGP EAHATETHCH ETEESTIKDS
   241  TTQKAGLPSK NLTVSQNQSE EFYNGPNRNR LLLKSDEESD KVISWSCKQL FDISLFRNPF
   301  FYIFTWSFLL SQLAYFIPTF HLVARAKTLG IDIMDASYLV SVAGILETVS QIISGWVADQ
   361  NWIKKYHYHK SYLILCGITN LLAPLATTFP LLMTYTICFA IFAGGYLALI LPVLVDLCRN
   421  STVNRFLGLA SFFAGMAVLS GPPIAGWLYD YTQTYNGSFY FSGICYLLSS VSFFFVPLAE
   481  RWKNSLT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 12
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 116 nTPM

Expression across tissuesHPA

Tissue

kidney: 116 nTPM
placenta: 27 nTPM
choroid plexus: 25 nTPM
ovary: 22 nTPM
epididymis: 21 nTPM
liver: 15 nTPM

Single-cell type

cardiomyocytes: 161 nCPM
proximal tubule cells: 126 nCPM
adipocytes: 111 nCPM
myonuclei: 110 nCPM
renal collecting duct principal cells: 97 nCPM
renal connecting tubule cells: 80 nCPM

Immune cell

memory B-cell: 1.5 nTPM
naive B-cell: 0.3 nTPM
neutrophil: 0.3 nTPM
classical monocyte: 0.2 nTPM
naive CD8 T-cell: 0.2 nTPM
eosinophil: 0.1 nTPM

Brain region

choroid plexus: 34 nTPM
cerebellum: 14 nTPM
white matter: 11 nTPM
hypothalamus: 11 nTPM
spinal cord: 11 nTPM
pons: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.05
gnomAD pLI: 0
gnomAD missense Z: 0.88
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A4 as an antibody target. Whether an autoantibody or antibody against SLC16A4 could matter depends on whether native SLC16A4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A4 is annotated at the cell surface, where native SLC16A4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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