Seroatlas · Human Serome Atlas

SLC16A7

Monocarboxylate transporter 2

Also known as: MCT2, MOT2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O60669
Gene
SLC16A7
Ensembl
ENSG00000118596
Chromosome
12
Canonical length
478 aa
Protein class
Metabolic proteins, Predicted membrane proteins, Transporters
Subcellular location
Nucleoplasm,Plasma membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene is a member of the monocarboxylate transporter family. Members in this family transport metabolites, such as lactate, pyruvate, and ketone bodies. The protein encoded by this gene catalyzes the proton-linked transport of monocarboxylates and has the highest affinity for pyruvate. This protein has been reported to be more highly expressed in prostate and colorectal cancer specimens when compared to control specimens. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

Canonical amino-acid sequenceUniProt

478 residues, UniProt reviewed canonical sequence.

>O60669|SLC16A7
     1  MPPMPSAPPV HPPPDGGWGW IVVGAAFISI GFSYAFPKAV TVFFKEIQQI FHTTYSEIAW
    61  ISSIMLAVMY AGGPVSSVLV NKYGSRPVVI AGGLLCCLGM VLASFSSSVV QLYLTMGFIT
   121  GLGLAFNLQP ALTIIGKYFY RKRPMANGLA MAGSPVFLSS LAPFNQYLFN TFGWKGSFLI
   181  LGSLLLNACV AGSLMRPLGP NQTTSKSKNK TGKTEDDSSP KKIKTKKSTW EKVNKYLDFS
   241  LFKHRGFLIY LSGNVIMFLG FFAPIIFLAP YAKDQGIDEY SAAFLLSVMA FVDMFARPSV
   301  GLIANSKYIR PRIQYFFSFA IMFNGVCHLL CPLAQDYTSL VLYAVFFGLG FGSVSSVLFE
   361  TLMDLVGAPR FSSAVGLVTI VECGPVLLGP PLAGKLVDLT GEYKYMYMSC GAIVVAASVW
   421  LLIGNAINYR LLAKERKEEN ARQKTRESEP LSKSKHSEDV NVKVSNAQSV TSERETNI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLC16A7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
12
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 32 nTPM
  • adipose tissue: 19 nTPM
  • kidney: 11 nTPM
  • stomach: 9.4 nTPM
  • pancreas: 9.2 nTPM
  • skin: 7.4 nTPM

Single-cell type

  • adipocytes: 749 nCPM
  • cardiomyocytes: 506 nCPM
  • parietal cells: 401 nCPM
  • distal convoluted tubule cells: 302 nCPM
  • renal collecting duct intercalated cells: 259 nCPM
  • renal connecting tubule cells: 258 nCPM

Immune cell

  • non-classical monocyte: 8.5 nTPM
  • naive CD8 T-cell: 5.8 nTPM
  • MAIT T-cell: 5.6 nTPM
  • gdT-cell: 4.3 nTPM
  • naive B-cell: 4.1 nTPM
  • T-reg: 3.9 nTPM

Brain region

  • cerebellum: 24 nTPM
  • choroid plexus: 21 nTPM
  • cerebral cortex: 21 nTPM
  • white matter: 21 nTPM
  • pons: 18 nTPM
  • medulla oblongata: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.01
gnomAD missense Z
0.28
DepMap mean gene effect
-0.1
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLC16A7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLC16A7 as an antibody target. Whether an autoantibody or antibody against SLC16A7 could matter depends on whether native SLC16A7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLC16A7 is annotated at the cell surface, where native SLC16A7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLC16A7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLC16A7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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