Seroatlas · Protein domains
Reverse transcriptase/Diguanylate cyclase domain
IPR043128
Definition
This superfamily comprises domains found in several proteins such as reverse transcriptase [[cite:PMID:23422558], [cite:PMID:20484498]], DNA polymerase IV and several nucleotide cyclases, such as the nucleotide-binding GGDEF domain. The representative domains have DNA-directed DNA polymerase, RNA-directed RNA polymerase and diguanylate cyclase activities, and are involved in viral replication, signal transduction, nucleotide binding, and hydrolysis of cyclic diguanylate.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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