ERVK-9
Endogenous retrovirus group K member 9 Pol protein
Also known as: POK9_HUMAN
Protein identityUniProt · HPA
OverviewNCBI Gene
No narrative summary is available for ERVK-9 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
1117 residues, UniProt reviewed canonical sequence.
>P63128|ERVK-9
1 MGQTKSKIKS KYASYLSFIK ILLKRGGVKV STKNLIKLFQ IIEQFCPWFP EQGTLDLKDW
61 KRIGKELKQA GRKGNIIPLT VWNDWAIIKA ALEPFQTEED SISVSDAPGS GIIDCNEKTR
121 KKSQKETESL HCEYVAEPVM AQSTQNVDYN QLQEVIYPET LKLEGKGPEL VGPSESKPRG
181 TSPLPAGQVP VTLQPQKQVK ENKTQPPVAY QYWPPAELQY RPPPESQYGY PGMPPAPQGR
241 APYPQPPTRR LNPTAPPSRQ GSELHEIIDK SRKEGDTEAW QFPVTLEPMP PGEGAQEGEP
301 PTVEARYKSF SIKILKDMKE GVKQYGPNSP YMRTLLDSIA HGHRLIPYDW EILAKSSLSP
361 SQFLQFKTWW IDGVQEQVRR NRAANPPVNI DADQLLGIGQ NWSTISQQAL MQNEAIEQVR
421 AICLRAWEKI QDPGSTCPSF NTVRQGSKEP YPDFVARLQD VAQKSIADEK ARKVIVELMA
481 YENANPECQS AIKPLKGKVP AGSDVISEYV KACDGIGGAM HKAMLMAQAI TGVVLGGQVR
541 TFGGKCYNCG QIGHLKKNCP VLNKQNITIQ ATTTGREPPD LCPRCKKGKH WASQCRSKFD
601 KNGQPLSGNE QRGQPQAPQQ TGAFPIQPFV PQGFQGQQPP LSQVFQGISQ LPQYNNCPPP
661 QVAVQQVDLC TIQAVSLLPG EPPQKIPTGV YGPLPEGTVG LILGRSSLNL KGVQIHTSVV
721 DSDYKGEIQL VISSSVPWSA SPGDRIAQLL LLPYIKGGNS EIKRIGGLGS TDPTGKAAYW
781 ASQVSENRPV CKAIIQGKQF EGLVDTGADV SIIALNQWPK NWPKQKAVTG LVGIGTASEV
841 YQSMEILHCL GPDNQESTVQ PMITSIPLNL WGRDLLQQWG AEITMPAPLY SPTSQKIMTK
901 RGYIPGKGLG KNEDGIKIPF EAKINQKREG IGYPFLGAAT IEPPKPIPLT WKTEKPVWVN
961 QWPLPKQKLE ALHLLANEQL EKGHIEPSFS PWNSPVFVIQ KKSGKWRMLT DLRAVNAVIQ
1021 PMGPLQPGLP SPAMIPKDWP LIIIDLKDCF FTIPLAEQDC EKFAFTIPAI NNKEPATRFQ
1081 WKVLPQGMLN SPTICQTFVG RALQPVKVFR LLYYSLYLocalizationUniProt · AlphaFold · HPA
Whether an antibody against ERVK-9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.43
OntologyGO
Biological processes
Molecular functions
- aspartic-type endopeptidase activity
- DNA-directed DNA polymerase activity
- RNA binding
- RNA-directed DNA polymerase activity
- RNA-DNA hybrid ribonuclease activity
- structural molecule activity
- zinc ion binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- G-patch domain
- Reverse transcriptase domain
- Zinc finger, CCHC-type
- Aspartic peptidase, active site
- Peptidase A2A, retrovirus, catalytic
- Beta-retroviral matrix protein
- Retrovirus capsid, C-terminal
- Retrovirus capsid, N-terminal
- Retroviral matrix protein
- Retropepsins
- Aspartic peptidase domain superfamily
- dUTPase-like
- dUTPase, trimeric
- Retropepsin-like catalytic domain
- dUTPase-like superfamily
- Zinc finger, CCHC-type superfamily
- Beta-retroviral matrix superfamily
- Reverse transcriptase/Diguanylate cyclase domain
- DNA/RNA polymerase superfamily
- Retroviral nucleocapsid Gag protein p24, C-terminal domain
- Primate lentivirus group Gag polyprotein-like
- Retroviral aspartyl protease
- Reverse transcriptase (RNA-dependent DNA polymerase)
- Zinc knuckle
- gag protein p24 N-terminal domain
- dUTPase
- G-patch domain
- Retroviral GAG p10 protein
- GAG-polyprotein viral zinc-finger
- Gag protein p24 C-terminal domain
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads ERVK-9 as an antibody target. Whether an autoantibody or antibody against ERVK-9 could matter depends on whether native ERVK-9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
ERVK-9 is annotated at the cell surface, where native ERVK-9 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label ERVK-9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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