Seroatlas · Human Serome Atlas

REV1

DNA repair protein REV1

Also known as: REV1_HUMAN, REV1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBZ9
Gene: REV1
Ensembl: ENSG00000135945
Chromosome: 2
Canonical length: 1251 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

1251 residues, UniProt reviewed canonical sequence.

>Q9UBZ9|REV1
     1  MRRGGWRKRA ENDGWETWGG YMAAKVQKLE EQFRSDAAMQ KDGTSSTIFS GVAIYVNGYT
    61  DPSAEELRKL MMLHGGQYHV YYSRSKTTHI IATNLPNAKI KELKGEKVIR PEWIVESIKA
   121  GRLLSYIPYQ LYTKQSSVQK GLSFNPVCRP EDPLPGPSNI AKQLNNRVNH IVKKIETENE
   181  VKVNGMNSWN EEDENNDFSF VDLEQTSPGR KQNGIPHPRG STAIFNGHTP SSNGALKTQD
   241  CLVPMVNSVA SRLSPAFSQE EDKAEKSSTD FRDCTLQQLQ QSTRNTDALR NPHRTNSFSL
   301  SPLHSNTKIN GAHHSTVQGP SSTKSTSSVS TFSKAAPSVP SKPSDCNFIS NFYSHSRLHH
   361  ISMWKCELTE FVNTLQRQSN GIFPGREKLK KMKTGRSALV VTDTGDMSVL NSPRHQSCIM
   421  HVDMDCFFVS VGIRNRPDLK GKPVAVTSNR GTGRAPLRPG ANPQLEWQYY QNKILKGKAA
   481  DIPDSSLWEN PDSAQANGID SVLSRAEIAS CSYEARQLGI KNGMFFGHAK QLCPNLQAVP
   541  YDFHAYKEVA QTLYETLASY THNIEAVSCD EALVDITEIL AETKLTPDEF ANAVRMEIKD
   601  QTKCAASVGI GSNILLARMA TRKAKPDGQY HLKPEEVDDF IRGQLVTNLP GVGHSMESKL
   661  ASLGIKTCGD LQYMTMAKLQ KEFGPKTGQM LYRFCRGLDD RPVRTEKERK SVSAEINYGI
   721  RFTQPKEAEA FLLSLSEEIQ RRLEATGMKG KRLTLKIMVR KPGAPVETAK FGGHGICDNI
   781  ARTVTLDQAT DNAKIIGKAM LNMFHTMKLN ISDMRGVGIH VNQLVPTNLN PSTCPSRPSV
   841  QSSHFPSGSY SVRDVFQVQK AKKSTEEEHK EVFRAAVDLE ISSASRTCTF LPPFPAHLPT
   901  SPDTNKAESS GKWNGLHTPV SVQSRLNLSI EVPSPSQLDQ SVLEALPPDL REQVEQVCAV
   961  QQAESHGDKK KEPVNGCNTG ILPQPVGTVL LQIPEPQESN SDAGINLIAL PAFSQVDPEV
  1021  FAALPAELQR ELKAAYDQRQ RQGENSTHQQ SASASVPKNP LLHLKAAVKE KKRNKKKKTI
  1081  GSPKRIQSPL NNKLLNSPAK TLPGACGSPQ KLIDGFLKHE GPPAEKPLEE LSASTSGVPG
  1141  LSSLQSDPAG CVRPPAPNLA GAVEFNDVKT LLREWITTIS DPMEEDILQV VKYCTDLIEE
  1201  KDLEKLDLVI KYMKRLMQQS VESVWNMAFD FILDNVQVVL QQTYGSTLKV T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against REV1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 22 nTPM

Expression across tissuesHPA

Tissue

tongue: 22 nTPM
cerebellum: 20 nTPM
epididymis: 16 nTPM
skeletal muscle: 15 nTPM
endometrium: 13 nTPM
cervix: 12 nTPM

Single-cell type

renal collecting duct intercalated cells: 222 nCPM
thyrotrophs: 215 nCPM
myonuclei: 215 nCPM
distal convoluted tubule cells: 202 nCPM
lactotrophs: 201 nCPM
pituicytes/fscs: 200 nCPM

Immune cell

naive CD4 T-cell: 0.9 nTPM
naive CD8 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.5 nTPM
memory CD8 T-cell: 0.4 nTPM
naive B-cell: 0.4 nTPM
gdT-cell: 0.3 nTPM

Brain region

cerebellum: 23 nTPM
choroid plexus: 16 nTPM
hypothalamus: 14 nTPM
white matter: 13 nTPM
cerebral cortex: 12 nTPM
basal ganglia: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.22
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

UmuC domain
BRCT domain
DNA polymerase, Y-family, little finger domain
HUWE1/REV1, ubiquitin-binding motif
BRCT domain superfamily
DNA polymerase, Y-family, little finger domain superfamily
Reverse transcriptase/Diguanylate cyclase domain
DNA/RNA polymerase superfamily
DNA polymerase IV/DNA polymerase iota-like, thumb domain
BRCA1 C Terminus (BRCT) domain
impB/mucB/samB family
impB/mucB/samB family C-terminal domain
Ubiquitin binding region
DNA polymerase-iota, thumb domain
DNA repair protein Rev1
DNA repair protein Rev1, C-terminal
Rev1, C-terminal domain superfamily
DNA repair protein REV1, ubiquitin-binding motif 1/2
DNA repair protein REV1 C-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of REV1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads REV1 as an antibody target. Whether an autoantibody or antibody against REV1 could matter depends on whether native REV1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

REV1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label REV1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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