Recoverin family
IPR028846
Definition
A number of other proteins including visinin, hippocalcin, neurocalcin, S-modulin, visinin-like protein, frequenin, guanylyl cyclase-activating proteins GCAP-1 and GCAP-2 PMID:9865963 belong to this family. All of the family members are generally N-myristoylated proteins containing four EF-hand calcium-binding consensus motifs. Recoverin is a Ca(2+) -binding protein that controls phosphorylation of the visual receptor rhodopsin by inhibiting rhodopsin kinase (GRK-1) in photoreceptor cells [[cite:PMID:16444517], [cite:PMID:8242744]]. It serves as a cancer-retina antigen that is expressed in retina and tumour cells and evokes antibodies and/or T cells in patients with cancer [[cite:PMID:16444517], [cite:PMID:22740915]].
15 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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