RCVRN

Protein identityUniProt · HPA

UniProt accession

P35243

Gene

RCVRN

Ensembl

ENSG00000109047

Chromosome

17

Canonical length

200 aa

Protein class

Plasma proteins, Predicted intracellular proteins, Transporters

Subcellular location

Mid piece,Principal piece

Quaternary structure

Homodimer

OverviewNCBI Gene

This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

200 residues, UniProt reviewed canonical sequence.

>P35243|RCVRN
     1  MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ SIYAKFFPDT
    61  DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ KLEWAFSLYD VDGNGTISKN
   121  EVLEIVMAIF KMITPEDVKL LPDDENTPEK RAEKIWKYFG KNDDDKLTEK EFIEGTLANK
   181  EILRLIQFEP QKVKEKMKNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RCVRN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

431 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RCVRN.

Disease | AutoantibodyPubMed

Conditions in which antibodies against RCVRN are reported. Each links to that disease's full target list.

• Lung Neoplasms 12
• Lupus Erythematosus, Systemic 3

Showing 2 of 8 — disease pages carrying at least 10 antigens.

ReferencesPubMed · IEDB

Publications for RCVRN from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.85

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

0.01

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• phototransduction
• regulation of calcium ion transport
• regulation of signal transduction
• signal transduction
• visual perception

Molecular functions

• calcium ion binding
• calcium sensitive guanylate cyclase activator activity

Cellular components

• dendrite
• perikaryon
• photoreceptor inner segment
• photoreceptor outer segment

Protein domainsUniProt · Pfam · InterPro

• EF-hand domain
• EF-hand domain pair
• EF-Hand 1, calcium-binding site
• Recoverin family
• EF-hand domain pair
• EF-hand domain pair

KeywordsUniProt

• Calcium
• Cell projection
• Disulfide bond
• Lipoprotein
• Membrane
• Metal-binding
• Myristate
• Oxidation
• Redox-active center
• Repeat
• Sensory transduction
• Vision