Seroatlas · Human Serome Atlas

GUCA1C

Guanylyl cyclase-activating protein 3

Also known as: GCAP3, GUC1C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95843
Gene: GUCA1C
Ensembl: ENSG00000138472
Chromosome: 3
Canonical length: 209 aa
Protein class: Predicted intracellular proteins
Subcellular location: Focal adhesion sites

OverviewNCBI Gene

Predicted to enable calcium ion binding activity and calcium sensitive guanylate cyclase activator activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in photoreceptor disc membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>O95843|GUCA1C
     1  MGNGKSIAGD QKAVPTQETH VWYRTFMMEY PSGLQTLHEF KTLLGLQGLN QKANKHIDQV
    61  YNTFDTNKDG FVDFLEFIAA VNLIMQEKME QKLKWYFKLY DADGNGSIDK NELLDMFMAV
   121  QALNGQQTLS PEEFINLVFH KIDINNDGEL TLEEFINGMA KDQDLLEIVY KSFDFSNVLR
   181  VICNGKQPDM ETDSSKSPDK AGLGKVKMK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GUCA1C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 275 nTPM

Expression across tissuesHPA

Tissue

retina: 275 nTPM
pancreas: 39 nTPM
heart muscle: 15 nTPM
stomach: 6 nTPM
choroid plexus: 4.9 nTPM
urinary bladder: 2.8 nTPM

Single-cell type

cone photoreceptor cells: 596 nCPM
early spermatids: 49 nCPM
parietal cells: 35 nCPM
pancreatic acinar cells: 26 nCPM
thymocytes: 22 nCPM
innate lymphoid cells: 19 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 2.3 nTPM
cerebral cortex: 2.2 nTPM
hypothalamus: 1.6 nTPM
hippocampal formation: 1.2 nTPM
amygdala: 0.7 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

photoreceptor disc membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GUCA1C as an antibody target. Whether an autoantibody or antibody against GUCA1C could matter depends on whether native GUCA1C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GUCA1C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GUCA1C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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