Seroatlas · Human Serome Atlas

VSNL1

Visinin-like protein 1

Also known as: HLP3, HPCAL3, HUVISL1, VILIP, VILIP-1, VISL1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62760
Gene: VSNL1
Ensembl: ENSG00000163032
Chromosome: 2
Canonical length: 191 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene is a member of the visinin/recoverin subfamily of neuronal calcium sensor proteins. The encoded protein is strongly expressed in granule cells of the cerebellum where it associates with membranes in a calcium-dependent manner and modulates intracellular signaling pathways of the central nervous system by directly or indirectly regulating the activity of adenylyl cyclase. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>P62760|VSNL1
     1  MGKQNSKLAP EVMEDLVKST EFNEHELKQW YKGFLKDCPS GRLNLEEFQQ LYVKFFPYGD
    61  ASKFAQHAFR TFDKNGDGTI DFREFICALS ITSRGSFEQK LNWAFNMYDL DGDGKITRVE
   121  MLEIIEAIYK MVGTVIMMKM NEDGLTPEQR VDKIFSKMDK NKDDQITLDE FKEAAKSDPS
   181  IVLLLQCDIQ K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VSNL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 725 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 725 nTPM
cerebellum: 509 nTPM
amygdala: 160 nTPM
hippocampal formation: 141 nTPM
hypothalamus: 128 nTPM
basal ganglia: 109 nTPM

Single-cell type

brain excitatory neurons: 393 nCPM
esophageal basal cells: 243 nCPM
brain inhibitory neurons: 219 nCPM
basal keratinocytes: 181 nCPM
esophageal suprabasal cells: 160 nCPM
other brain neurons: 151 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 1,751 nTPM
white matter: 749 nTPM
basal ganglia: 535 nTPM
pons: 332 nTPM
midbrain: 294 nTPM
hippocampal formation: 271 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.63
gnomAD pLI: 0.46
gnomAD missense Z: 2.6
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VSNL1 as an antibody target. Whether an autoantibody or antibody against VSNL1 could matter depends on whether native VSNL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VSNL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VSNL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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