Seroatlas · Human Serome Atlas

HPCAL4

Hippocalcin-like protein 4

Also known as: DKFZp761G122, HLP4, HPCL4_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UM19
Gene: HPCAL4
Ensembl: ENSG00000116983
Chromosome: 1
Canonical length: 191 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

191 residues, UniProt reviewed canonical sequence.

>Q9UM19|HPCAL4
     1  MGKTNSKLAP EVLEDLVQNT EFSEQELKQW YKGFLKDCPS GILNLEEFQQ LYIKFFPYGD
    61  ASKFAQHAFR TFDKNGDGTI DFREFICALS VTSRGSFEQK LNWAFEMYDL DGDGRITRLE
   121  MLEIIEAIYK MVGTVIMMRM NQDGLTPQQR VDKIFKKMDQ DKDDQITLEE FKEAAKSDPS
   181  IVLLLQCDMQ K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HPCAL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 123 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 123 nTPM
basal ganglia: 104 nTPM
amygdala: 98 nTPM
cerebellum: 92 nTPM
hippocampal formation: 80 nTPM
hypothalamus: 52 nTPM

Single-cell type

brain inhibitory neurons: 41 nCPM
brain excitatory neurons: 40 nCPM
other brain neurons: 31 nCPM
retinal amacrine cells: 27 nCPM
retinal bipolar cells: 24 nCPM
adrenal medulla cells: 21 nCPM

Immune cell

memory CD4 T-cell: 3 nTPM
naive CD4 T-cell: 2.6 nTPM
T-reg: 2.2 nTPM
naive CD8 T-cell: 0.9 nTPM
total PBMC: 0.9 nTPM
gdT-cell: 0.5 nTPM

Brain region

cerebral cortex: 198 nTPM
basal ganglia: 194 nTPM
hippocampal formation: 151 nTPM
hypothalamus: 130 nTPM
amygdala: 129 nTPM
white matter: 102 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: 0.95
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HPCAL4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

LITAF

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HPCAL4 as an antibody target. Whether an autoantibody or antibody against HPCAL4 could matter depends on whether native HPCAL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HPCAL4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HPCAL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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