Seroatlas · Human Serome Atlas

CLXN

Calaxin

Also known as: CLXN_HUMAN, EFCAB1, FLJ11767, ODAD5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HAE3
Gene: CLXN
Ensembl: ENSG00000034239
Chromosome: 8
Canonical length: 211 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Mid piece,Principal piece

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including cilium movement; outer dynein arm assembly; and regulation of flagellated sperm motility. Located in sperm flagellum. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

211 residues, UniProt reviewed canonical sequence.

>Q9HAE3|CLXN
     1  MNRKKLQKLT DTLTKNCKHF NKFEVNCLIK LFYDLVGGVE RQGLVVGLDR NAFRNILHVT
    61  FGMTDDMIMD RVFRGFDKDN DGCVNVLEWI HGLSLFLRGS LEEKMKYCFE VFDLNGDGFI
   121  SKEEMFHMLK NSLLKQPSEE DPDEGIKDLV EITLKKMDHD HDGKLSFADY ELAVREETLL
   181  LEAFGPCLPD PKSQMEFEAQ VFKDPNEFND M

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CLXN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 86 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 86 nTPM
choroid plexus: 51 nTPM
testis: 36 nTPM
ovary: 14 nTPM
hippocampal formation: 12 nTPM
endometrium: 12 nTPM

Single-cell type

late spermatids: 736 nCPM
early spermatids: 622 nCPM
respiratory ciliated cells: 518 nCPM
fallopian tube ciliated cells: 451 nCPM
epididymal efferent duct ciliated cells: 348 nCPM
ependymal cells: 268 nCPM

Immune cell

neutrophil: 1.2 nTPM
MAIT T-cell: 0.3 nTPM
NK-cell: 0.3 nTPM
memory B-cell: 0.2 nTPM
memory CD4 T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM

Brain region

choroid plexus: 48 nTPM
medulla oblongata: 31 nTPM
midbrain: 27 nTPM
spinal cord: 20 nTPM
white matter: 18 nTPM
hypothalamus: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CLXN.

Disease | AllUniProt

Conditions CLXN is implicated in, by any mechanism.

Ciliary dyskinesia, primary, 53 (CILD53) MIM:620642

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 32 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Ciliary dyskinesia, primary, 53

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.18
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calcium ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CLXN as an antibody target. Whether an autoantibody or antibody against CLXN could matter depends on whether native CLXN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CLXN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CLXN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...