Seroatlas · Human Serome Atlas

KCNIP2

A-type potassium channel modulatory protein KCNIP2

Also known as: KCHIP2, KCIP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NS61
Gene
KCNIP2
Ensembl
ENSG00000120049
Chromosome
10
Canonical length
270 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q9NS61|KCNIP2
     1  MRGQGRKESL SDSRDLDGSY DQLTGHPPGP TKKALKQRFL KLLPCCGPQA LPSVSETLAA
    61  PASLRPHRPR LLDPDSVDDE FELSTVCHRP EGLEQLQEQT KFTRKELQVL YRGFKNECPS
   121  GIVNEENFKQ IYSQFFPQGD SSTYATFLFN AFDTNHDGSV SFEDFVAGLS VILRGTVDDR
   181  LNWAFNLYDL NKDGCITKEE MLDIMKSIYD MMGKYTYPAL REEAPREHVE SFFQKMDRNK
   241  DGVVTIEEFI ESCQKDENIM RSMQLFDNVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
287 nTPM

Expression across tissuesHPA

Tissue

  • heart muscle: 287 nTPM
  • basal ganglia: 247 nTPM
  • adipose tissue: 214 nTPM
  • hippocampal formation: 94 nTPM
  • cerebral cortex: 78 nTPM
  • amygdala: 75 nTPM

Single-cell type

  • adipocytes: 231 nCPM
  • brain inhibitory neurons: 87 nCPM
  • cardiomyocytes: 61 nCPM
  • retinal bipolar cells: 46 nCPM
  • brain excitatory neurons: 33 nCPM
  • retinal horizontal cells: 28 nCPM

Immune cell

  • naive B-cell: 1.5 nTPM
  • memory B-cell: 0.9 nTPM
  • eosinophil: 0.7 nTPM
  • intermediate monocyte: 0.5 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM

Brain region

  • basal ganglia: 218 nTPM
  • hippocampal formation: 134 nTPM
  • cerebral cortex: 107 nTPM
  • amygdala: 83 nTPM
  • white matter: 53 nTPM
  • thalamus: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.02
gnomAD missense Z
1.87
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNIP2 as an antibody target. Whether an autoantibody or antibody against KCNIP2 could matter depends on whether native KCNIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNIP2 is annotated at the cell surface, where native KCNIP2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNIP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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