Seroatlas · Human Serome Atlas

HPCAL1

Hippocalcin-like protein 1

Also known as: BDR1, HLP2, HPCL1_HUMAN, VILIP-3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P37235
Gene: HPCAL1
Ensembl: ENSG00000115756
Chromosome: 2
Canonical length: 193 aa
Protein class: Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2012]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>P37235|HPCAL1
     1  MGKQNSKLRP EVLQDLRENT EFTDHELQEW YKGFLKDCPT GHLTVDEFKK IYANFFPYGD
    61  ASKFAEHVFR TFDTNGDGTI DFREFIIALS VTSRGKLEQK LKWAFSMYDL DGNGYISRSE
   121  MLEIVQAIYK MVSSVMKMPE DESTPEKRTD KIFRQMDTNN DGKLSLEEFI RGAKSDPSIV
   181  RLLQCDPSSA SQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against HPCAL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 411 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 411 nTPM
cerebral cortex: 214 nTPM
hypothalamus: 156 nTPM
amygdala: 127 nTPM
lung: 98 nTPM
endometrium: 83 nTPM

Single-cell type

neutrophils: 666 nCPM
alveolar cells type 1: 562 nCPM
somatotrophs: 395 nCPM
goblet cells: 372 nCPM
paneth cells: 306 nCPM
extravillous trophoblasts: 258 nCPM

Immune cell

neutrophil: 70 nTPM
eosinophil: 62 nTPM
classical monocyte: 51 nTPM
naive CD4 T-cell: 46 nTPM
myeloid DC: 44 nTPM
intermediate monocyte: 40 nTPM

Brain region

cerebellum: 344 nTPM
pons: 259 nTPM
basal ganglia: 253 nTPM
hypothalamus: 244 nTPM
medulla oblongata: 237 nTPM
cerebral cortex: 237 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.89
gnomAD missense Z: 2.4
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of HPCAL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads HPCAL1 as an antibody target. Whether an autoantibody or antibody against HPCAL1 could matter depends on whether native HPCAL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

HPCAL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label HPCAL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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