Seroatlas · Human Serome Atlas

KCNIP4

Kv channel-interacting protein 4

Also known as: CALP, KCHIP4, KCIP4_HUMAN, MGC44947

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6PIL6
Gene
KCNIP4
Ensembl
ENSG00000185774
Chromosome
4
Canonical length
250 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

250 residues, UniProt reviewed canonical sequence.

>Q6PIL6|KCNIP4
     1  MNVRRVESIS AQLEEASSTG GFLYAQNSTK RSIKERLMKL LPCSAAKTSS PAIQNSVEDE
    61  LEMATVRHRP EALELLEAQS KFTKKELQIL YRGFKNECPS GVVNEETFKE IYSQFFPQGD
   121  STTYAHFLFN AFDTDHNGAV SFEDFIKGLS ILLRGTVQEK LNWAFNLYDI NKDGYITKEE
   181  MLDIMKAIYD MMGKCTYPVL KEDAPRQHVE TFFQKMDKNK DGVVTIDEFI ESCQKDENIM
   241  RSMQLFENVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNIP4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 36 nTPM
  • basal ganglia: 24 nTPM
  • cerebellum: 23 nTPM
  • hypothalamus: 21 nTPM
  • amygdala: 19 nTPM
  • retina: 17 nTPM

Single-cell type

  • brain excitatory neurons: 9,555 nCPM
  • brain inhibitory neurons: 7,944 nCPM
  • thyrotrophs: 7,154 nCPM
  • oligodendrocyte progenitor cells: 6,715 nCPM
  • retinal amacrine cells: 5,853 nCPM
  • other brain neurons: 4,308 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 65 nTPM
  • basal ganglia: 49 nTPM
  • pons: 47 nTPM
  • cerebellum: 46 nTPM
  • hypothalamus: 45 nTPM
  • white matter: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.44
gnomAD pLI
0.82
gnomAD missense Z
1.39
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNIP4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNIP4 as an antibody target. Whether an autoantibody or antibody against KCNIP4 could matter depends on whether native KCNIP4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNIP4 is annotated at the cell surface, where native KCNIP4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNIP4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNIP4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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