Seroatlas · Human Serome Atlas

KCNIP3

Calsenilin

Also known as: CSEN, CSEN_HUMAN, DREAM, KCHIP3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y2W7
Gene
KCNIP3
Ensembl
ENSG00000115041
Chromosome
2
Canonical length
256 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles
Secretome location
Intracellular and membrane
Quaternary structure
Homomultimer

OverviewNCBI Gene

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

256 residues, UniProt reviewed canonical sequence.

>Q9Y2W7|KCNIP3
     1  MQPAKEVTKA SDGSLLGDLG HTPLSKKEGI KWQRPRLSRQ ALMRCCLVKW ILSSTAPQGS
    61  DSSDSELELS TVRHQPEGLD QLQAQTKFTK KELQSLYRGF KNECPTGLVD EDTFKLIYAQ
   121  FFPQGDATTY AHFLFNAFDA DGNGAIHFED FVVGLSILLR GTVHEKLKWA FNLYDINKDG
   181  YITKEEMLAI MKSIYDMMGR HTYPILREDA PAEHVERFFE KMDRNQDGVV TIEEFLEACQ
   241  KDENIMSSMQ LFENVI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 30 nTPM
  • parathyroid gland: 25 nTPM
  • thymus: 23 nTPM
  • amygdala: 18 nTPM
  • hippocampal formation: 15 nTPM
  • seminal vesicle: 14 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 103 nCPM
  • peritubular myoid cells: 62 nCPM
  • leydig cells: 45 nCPM
  • lactotrophs: 43 nCPM
  • melanocytes: 32 nCPM
  • salivary duct cells: 30 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 32 nTPM
  • amygdala: 26 nTPM
  • white matter: 23 nTPM
  • basal ganglia: 23 nTPM
  • hippocampal formation: 21 nTPM
  • thalamus: 20 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.04
gnomAD missense Z
0.89
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNIP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNIP3 as an antibody target. Whether an autoantibody or antibody against KCNIP3 could matter depends on whether native KCNIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNIP3 is annotated at the cell surface, where native KCNIP3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNIP3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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