Seroatlas · Human Serome Atlas

KCNIP1

A-type potassium channel modulatory protein KCNIP1

Also known as: KCHIP1, KCIP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NZI2
Gene
KCNIP1
Ensembl
ENSG00000182132
Chromosome
5
Canonical length
227 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

227 residues, UniProt reviewed canonical sequence.

>Q9NZI2|KCNIP1
     1  MGAVMGTFSS LQTKQRRPSK DIAWWYYQYQ RDKIEDELEM TMVCHRPEGL EQLEAQTNFT
    61  KRELQVLYRG FKNECPSGVV NEDTFKQIYA QFFPHGDAST YAHYLFNAFD TTQTGSVKFE
   121  DFVTALSILL RGTVHEKLRW TFNLYDINKD GYINKEEMMD IVKAIYDMMG KYTYPVLKED
   181  TPRQHVDVFF QKMDKNKDGI VTLDEFLESC QEDDNIMRSL QLFQNVM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KCNIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
52 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 52 nTPM
  • amygdala: 42 nTPM
  • hypothalamus: 42 nTPM
  • cerebral cortex: 38 nTPM
  • midbrain: 28 nTPM
  • hippocampal formation: 25 nTPM

Single-cell type

  • microglia: 600 nCPM
  • peritubular myoid cells: 544 nCPM
  • retinal horizontal cells: 457 nCPM
  • cardiomyocytes: 431 nCPM
  • oligodendrocyte progenitor cells: 423 nCPM
  • leydig cells: 319 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 40 nTPM
  • spinal cord: 32 nTPM
  • midbrain: 27 nTPM
  • basal ganglia: 27 nTPM
  • pons: 23 nTPM
  • medulla oblongata: 23 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about KCNIP1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 22 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.74
gnomAD pLI
0
gnomAD missense Z
1.66
DepMap mean gene effect
0.12
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KCNIP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KCNIP1 as an antibody target. Whether an autoantibody or antibody against KCNIP1 could matter depends on whether native KCNIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KCNIP1 is annotated at the cell surface, where native KCNIP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label KCNIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KCNIP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...