PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

Definition

This superfamily represents a structural domain consisting of a TIM β/α-barrel. These domains are found in several phospholipase C (PLC) like phosphodiesterases, including: Mammalian phospholipase C isozyme D1 PMID:8784353. Bacterial phosphatidylinositol-specific phospholipase C PMID:9335537. Glycerophosphodiester phosphodiesterases, such as GlpQ from Escherichia coli and UgpQ from Agrobacterium tumefaciens PMID:16909422. Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyse phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. PLC enzymes often play central roles in various signalling cascades PMID:18691970.

25 human proteins with this domain

Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.

Download CSV (25 proteins: gene, accession, name)

• GDE1
• GDPD1
• GDPD2
• GDPD3
• GDPD4
• GDPD5
• GPCPD1
• PLCB1
• PLCB2
• PLCB3
• PLCB4
• PLCD1
• PLCD3
• PLCD4
• PLCE1
• PLCG1
• PLCG2
• PLCH1
• PLCH2
• PLCL1
• PLCL2
• PLCXD1
• PLCXD2
• PLCXD3
• PLCZ1